门静脉高压症断流术后胃粘膜病变致再出血的细胞动力学机理研究

Cytokinetic Mechanism of Rebleeding Caused by Gastric Mucosal Disease after Disconnective Operation Treatment of Portal Hypertension

用硫代己■胺复制大鼠肝硬变合并门静脉高压性胃病模型，并作断流手术．应用放射自显影3H－TdR两次脉冲标记法研究断流术后细胞动力学变化，结果发现，断流术后大鼠胃粘膜细胞DNA合成期，细胞周期较正常组及模型组均明显延长（P＜0．01）．标记指数降低（P＜0．01）．多数变化主要在胃体部，而胃卖部变化不大．提示断流术后冒粘膜细胞增殖能力极度低下，削弱了粘膜自身防御能力，可能是胃粘膜病变导致再出血的因素之一．

The Cytokinetic mechanism of rebleeding after disconnective operation was studied. The model rats induced by thioacetamide with cirrhosis and portal hypertensive gastropathy were performed by disconnective operations. The changes of gastric mucosal cytokinetics were investigated by applying 3H-TdR double pulse labelling technique after operations. The results indicated that TS and Tc stage of gastric mucosal cells of the operative rats were prolonged (P< 0.01), apparent lowering of labelling index appeared (P< 0.01) Com.pared with that in normal and model rats. The significant changes were only found in the region of gastric body but not at the antral portion- It showed that weak prolifrative abability of gastric mucosal cells due to disconnection could be one of the factors of rebleeding.