蒿甲醚注射液治疗恶性疟121例临床分析

Injectio Artemetheri in the Treatment of Falciparum Malaria:Clinical Analysis of 121 Cases

本文报道采用蒿甲醚注射液5天疗程成人总量480mg 治疗恶性疟121例的结果。患者平均退热时间为21.3±11.7小时,平均原虫转阴时间为75.9±15.3小时,其中100例追踪观察至28天,有5例(5%)复燃。与此同时,对30例病人进行体外疟原虫对氯喹敏感性测定,结果表明抗性率占56.7%,由此说明蒿甲醚注射液治疗抗氯喹恶性疟疗效良好。发现个别病人出现药物热,部分病人出现一过性网织红细胞下降至略低于正常低限值的毒副反应。根据研究结果,作者认为蒿甲醚注射液总量480mg 5天给药方案可推荐作为今后临床扩大试用的方案。

Treated with Injectio Artemetheri for 5 days in a total dose of 480mg,121adult patients with falcipar(?)m malaria have been reported.The mean timefor fever subsidence was 21.3±11.7 hrs,and for asexual parasite clearance,75.9±15.3 hrs.Of all the cases 100 were subjected to a 28-day follow-up,and5(5%)of them had recrudescence.In the meanwhile,30 assays of sensitivityof malarial parasite to chloroquine in vitro showed that the rate of drug-fastwas 56.7%.It is indicated that Injectio Artemetheri is effective forchloroquine-resistant falciparum malaria.The toxic and side effects includingdrug-fever and the transient decrease of reticulocyte were observed in fewpatients.Based on these results,it is considered that the program of a totaldose of 480rag of Injectio Artemetheri for 5 days can be recommended clini-cally for extensive trial in the future.