正常妊娠与妊高征患者钙调节因子水平的研究

Serum Calcium regulating Factors Levels in Women with Normal Pregnancy and with Pregnancy Inoluced Hypertension

对１４５名健康孕妇（不同孕期及产后）、９０例中、重度妊娠高血压综合征（简称妊高征）患者，以及做为对照的非孕妇女的血清进行钙（Ｃａ）、磷（Ｐ）、碱性磷酸酶（ＡＫＰ）、甲状旁腺素（ＰＴＨ）、降钙素（ＣＴ）、２５羟维生素Ｄ３［２５（ＯＨ）Ｄ３］及骨钙素（ＢＧＰ）等７项检验。并对妊娠中期补钙与未补钙的孕妇的妊高征发生率进行比较。结果：各项检测指标随孕周增加及产后有明显变化。正常妊娠钙代谢调节代偿性平衡，而妊高征患者钙代谢调节失衡。孕中期补钙组的妊高征发生率明显低于对照组。提示妊高征的发生与钙缺乏有着密切的关系，孕中期补钙有利于预防妊高征的发生。

Seven items of serum idices related to calcium regulation were measured in 145 normal pregnant women (with different gestation periods and at postpartum stage), 90 cases with moderate and severe PIH and non pregnant women.Some of them were given calcium supplement from 2nd trimester to term.Serum calcium,phosphorus,alkaline phosphatase,thyroxine calcitonin,25 (OH)D 3,and osteocalcin were measured in 1 st,2 nd,3 rd trimester and after delivery. PIH morbidities were compared between calcium supplement and no supplement .Results showed that each index was increased with the increase in gestation week and at postpartum stage in normal pregnancy, but not in PIH.Calcium supplement in 2 nd trimester reduced the PIH morbidity significantly.Calcium deficiency could increase PIH morbility and calicium supplement from 2 nd trimester could reduce the PIH morbidity.