家族性氨基糖甙类抗生素耳中毒易感性与 HLA 相关性的研究

Susceptibility of Genetic Aminoglycoside induced Hearing Loss

以人类白细胞抗原（ＨＬＡ）为遗传标志，选用８个随机婚配的氨基糖甙类耳中毒（以下简称耳中毒）家庭，测定其ＨＬＡ抗原型别，根据分型结果进行连锁分析（Ｌｏｄｓ法）、单倍型分离分析和患病同胞对的分析。结果表明，家族性耳中毒易感基因很可能与ＨＬＡ基因连锁，并以显性方式遗传。

e notice that the aminoglycoside induced hearing loss often happens with an obviously high familial susceptibility, showing a mother to child genetic phenomenon. To find the immunogenetic mechanism of this disease,we chose 8 affected kindreds, in each of which there was no blood relationship between father and mother, to test the family members HLA types. The linkage analysis (with Lods Method), haploid analysis and affected sib pairs analysis were done after the typing. The results suggest that the gene(s) which affects the susceptibility of antibiotic induced hearing loss is possibly linked with the HLA genes and is inherited according to a model of autosomal dominant inheritance.