Toll样受体与冠心病

Toll-like receptor in coronary atherosclerotic heart disease

冠心病是一种慢性炎症性免疫性疾病,冠心病的各种危险因素通过对Toll样受体家族基因和其下游炎症网络的调控,参与冠心病的炎症和免疫反应。炎症和免疫反应损伤血管,引起脂质浸润,平滑肌细胞增殖,导致斑块形成,炎症免疫反应又可以促进斑块的发展。Toll样受体介导冠状动脉粥样斑块的发生、进展、斑块不稳定乃至破裂等。干预Toll样受体家族,可能是冠状动脉粥样硬化性心脏病防治的新靶点。

Coronary atherosclerotie heart disease （CHD） is a chronic inflammatory and autoimmune disease. Various risk factors of CHD involved in the infflammatory and immune responses through regulated toll-like receptor genes and its downstream inflammatory network. Inflammation and immune responses of CHD injury vascular,cause lipid infiltration and smooth muscle cell proliferation, which will result in coronary arterial plaque formation. Moreover, inflammatory and immune response of CHD can promote the development of plaques. Toll-like receptors mediated coronary atherosclerosis progress and plaque rupture. To intervene toll-like receptor family, may be a new target for CHD prevention and therapy.