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SR-BⅠ生物学作用的分子机制

Current progression in the molecular mechanism of scavenger receptor class B type Ⅰ playing biological function
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摘要 B族Ⅰ型清道夫受体(SR-BⅠ)属于CD36超家族成员。作为高密度脂蛋白受体,能通过多种机制对动脉粥样硬化发挥保护效应。近年来,随着基因敲除技术和转基因技术的广泛应用,已经证实SR-BⅠ不但在脂蛋白代谢和胆固醇转运中发挥着重要作用,而且在一氧化氮代谢、肝炎病毒感染、正常红细胞成熟和雌性生育等方面也显示出较强的调节作用。本文综述了SR-BⅠ行使其生物学作用的分子机制。 The scavenger receptor class B type I （SR-B I ） ,a member of macrophage scavenger receptor superfamily,is considered a high density lipoprotein receptor. This receptor is known to possess atherosclerotic protective property through multiple mechanisms. Recently, with the wide application of gene knock-out and transgenic techniques, it has been confirmed that SR-BI plays a pivotal role in lipoprotein metabolism and cho-lesterol transport, and has a notable regulative function in nitrogen monoxidum metabolism, hepatitis virus infection, normal erythrocyte maturation and female reproduction. The present paper summarized the molecular mechanism of SR-BI playing biological function.
作者 麦海妍 凌文华
机构地区 中山大学附属第一医院营养科 中山大学公共卫生学院营养系
出处 《国际内科学杂志》 CAS 2007年第10期574-576,584,共4页 International Journal of Internal Medicine
关键词 B族I型清道夫受体 动脉粥样硬化 一氧化氮合酶 PDZKI Scavenger receptor class B type I Atherosclerosis Nitricoxide synthase PDZKI
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献24

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  • 2Connelly MA, De La Llera-Moya M, Peng Y, et al. Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I. J Biol Chem, 2003,278 ( 28 ) : 25773-25782.
  • 3Parathath S, Sahoo D, Darlington YF, et al. Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester. J Biol Chem, 2004, 279 ( 24 ) :24976- 24985.
  • 4Mineo C,Yuhanna IS, Quon MJ,et al. High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. J Biol Chem, 2003,278 ( 11 ) :9142-9149.
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国际内科学杂志
2007年 第10期

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