摘要
B族Ⅰ型清道夫受体(SR-BⅠ)属于CD36超家族成员。作为高密度脂蛋白受体,能通过多种机制对动脉粥样硬化发挥保护效应。近年来,随着基因敲除技术和转基因技术的广泛应用,已经证实SR-BⅠ不但在脂蛋白代谢和胆固醇转运中发挥着重要作用,而且在一氧化氮代谢、肝炎病毒感染、正常红细胞成熟和雌性生育等方面也显示出较强的调节作用。本文综述了SR-BⅠ行使其生物学作用的分子机制。
The scavenger receptor class B type I (SR-B I ) ,a member of macrophage scavenger receptor superfamily,is considered a high density lipoprotein receptor. This receptor is known to possess atherosclerotic protective property through multiple mechanisms. Recently, with the wide application of gene knock-out and transgenic techniques, it has been confirmed that SR-BI plays a pivotal role in lipoprotein metabolism and cho-lesterol transport, and has a notable regulative function in nitrogen monoxidum metabolism, hepatitis virus infection, normal erythrocyte maturation and female reproduction. The present paper summarized the molecular mechanism of SR-BI playing biological function.
出处
《国际内科学杂志》
CAS
2007年第10期574-576,584,共4页
International Journal of Internal Medicine