PKB/Akt-NF-κB通路与糖尿病血管内皮细胞功能的调节

Effect of PKB/Akt kinase-nuclear factor kappa B signaling pathway on vascular endothelial cells in diabetic patients

糖尿病血管病变是糖尿病患者致死率和致残率增高的最主要原因。血管内皮细胞是介于循环血液和管壁之间的第一道屏障,与糖尿病血管病变的病理生理联系尤为密切。蛋白激酶B(PKB)/Akt、核因子(NF)-κB是细胞内重要的信号分子,它们之间相互作用、相互影响,在血管内皮细胞中协同调控内皮细胞的炎症、凋亡、增殖等。本文对PKB/Akt-NF-κB的关系及其对糖尿病血管内皮细胞功能的调节作一综述。

Vascular complications are major causes of disability and death in patients with diabetes mellitus. Vascular endothelial cells（VECs） , because of their strategic anatomic position between the circulating blood and the vessel wall, may be particularly relevant to the pathophysiology of vascular complications of diabetes. Akt kinase and Nuclear Factor kappa B（NF-KB） serve as signal transducers and there are cross-talks at several levels between them. A collaborative action between NF-KB and Akt in endothelial cells has been demonstrated to regulate the transcription of a number of genes responsible for inflammation, apoptosis and proliferation. In this reveiw we focused on the relationship between Akt kinase and NF-KB and their regulation on the function of VECs in diabetic patients.