盐酸法舒地尔与尼莫地平治疗蛛网膜下腔出血术后脑血管痉挛的对比研究

Comparison Study of Hydroxyfasudil Injection for Treatment of Vasospasm of Postoperative Subarachnoid Hemorrhage

目的探讨盐酸法舒地尔对蛛网膜下腔出血术后脑血管痉挛的治疗效果。方法将60例蛛网膜下腔出血患者随机分成两组,对照组30例术后除常规治疗外,给予尼莫地平注射液治疗;治疗组30例除常规治疗外,给予盐酸法舒地尔注射液治疗。两组均以疗效标准判断疗效并测定两组治疗前后得分。结果盐酸法舒地尔对蛛网膜下腔出血术后脑出血痉挛的治疗有积极疗效。两组间差异无统计学意义。结论盐酸法舒地尔具有安全可靠和有效性,无毒副作用及不良反应,是一种新型抗脑血管痉挛药物。

Objective To observe fasudi! injection＇ s medical efficiency in treatment of vasospasm of postoperative subarachnoid hemorrhage（SAH）. Methods 60 patients of postoperative subarachnoid hemorrhage were randomly dirided into two group. Control group（ 30 cases） were given usual treatment and nimodipine injection. Treatment group were given usual treatment and tasudil injection. The result were evaluated with the asscssment standard of the fourth national scholarship conference of cerebral vessel disease in 60 patients were measure pre-and post-course of treatment. Results The fasudil injection for treatment of postoperative subarachrioid hemorrhage may obviously improve the effect of treatment. There were no change graded of GCS in two groups after treatment. Conclusion This study shows FSD to be a safe,effective and useful drug on CVS after SAH,as a new unique anti-vaso spasm agent.