摘要
本实验研究了除草剂百草枯对大鼠及其胎儿毒性作用。结果表明,雄性大鼠一次性接1/10LD50、1/5LD50和1/2LD50的百草枯不会引起雄性生殖细胞的突变;百草枯在1/10LD50、1/20LD50和1/40LD50的剂量下不能影响雄性大鼠精子活率的改变和精子畸形率的上升,却可以影响睾丸组织中碱性磷酸酶(AKP或ALP)的活性,对睾丸造成一定程度的损伤;百草枯可导致大鼠胎儿特殊循环系统动脉管(DA)的收缩,对其存在毒性作用,并且动脉管内径与染毒剂量剂量之间存在显著的剂量—效应关系。
The toxic effect of PQ on rats and fetus was studied in this paper. The results indicated that PQ cannot induce germinal mutation at the dose of 1/10 LD50, 1/5 LD50 and 1/2 LD50 and also cannot enhance the rat＇s spermatic activity ratio or induce gential toxicity on rats at the dose of 1/40 LD50, 1/20 LD50 and 1/10 LD50. But PQ can affect the activity of AKP（ALP） by digestive tract at these doses; PQ can induce contraction of DA of embryo showing that PQ has embryonic toxicity; with the dose increasing, the inner diameter of DA decreasing, indicating that there is dose-reaction relationship between the dose and inner diameter of DA.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第10期510-513,共4页
Food Science
基金
吉林省科技厅资助项目(20050548)
