热疗对造血系统恶性肿瘤患者血清可溶性白介素-2受体的影响

Effects of hyperthrmia on serum soluble interleukin 2 receptor of patient with tumors in hematopoietic system

目的观察高强度聚焦超声热疗前后造血系统恶性肿瘤患者血清可溶性白介素-2受体的变化及意义。方法采用双抗夹心ELISA法测定32例造血系统恶性肿瘤患者热疗前后血清可溶性白介素-2受体水平。结果热疗后患者血清可溶性白介素-2受体水平[(61.56±21.83)pmol/L]较治疗前[(100.75±39.12)pmol/L]显著降低(P<0.05)。结论高强度聚焦超声热疗后,造血系统恶性肿瘤患者血清可溶性白介素-2受体水平降低,可能表明造血系统恶性肿瘤患者免疫功能的改善。

Objective To study the effects of hyperthermia with high intensity focused ultrasound on serum soluble interleukin 2 receptor（slL-2R）of the patients with tumor in hematopoietic system.Methods The level changes of slL-2R were evaluated with ELISA method before and ＂after hyperthermia.Results The level of slL-2R after tumor hyperthermia with high intensity focused ultrasound was significant lower than the level before hyperthermia.Conclusion Evaluating the level of slL-2R is helpful to know the immunity state of the patients and the level of slL-2R may be the markers of the prognosis of the patients.