摘要
Objective:To evaluate the clinical application of proton magnetic resonance spectroscopy(1HMRS)in patients with radiotherapy treated intracranial tumors.Methods:Forty patients with intracranial tumors underwent multivoxel 1HMRS examination before and after radiotherapy.The concentrations of N-acetyl aspartate(NAA),choline(Cho)and creatine(Cr) were obtained both in the tumors and the contralateral normal brain regions.The ratios of NAA/Cr,Cho/Cr and Cho/NAA were calculated at the same time and follow-up one year.Results:(1)After radiotherapy,tumors inhibited by radiation had decreased Cho,NAA and Cr on proton MRS.Some cases showed necrotic wave.(2)During the one year follow-up,local tumor recurred in 8 cases and their Cho and Cho/NAA increased high again.Other cases without recurrence,1HMRS showed no change.Conclusion:Multivoxel proton MR spectroscopy is available for study of tumor metabolites after radiotherapy and it is a valuable method in the evaluation of radiotherapy treated tumors.
Objective： To evaluate the clinical application of proton magnetic resonance spectroscopy （1HMRS） in patients with radiotherapy treated intracranial tumors. Methods： Forty patients with intracranial tumors underwent multivoxel 1HMRS examination before and after radiotherapy. The concentrations of N-acetyl aspartate （NAA）, choline （Cho） and creatine （Cr） were obtained both in the tumors and the contralateral normal brain regions, The ratios of NANCr, Cho/Cr and Cho/NAA were calculated at the same time and follow-up one year. Results： （1） After radiotherapy, tumors inhibited by radiation had decreased Cho, NAA and Cr on proton MRS. Some cases showed necrotic wave. （2） During the one year follow-up, local tumor recurred in 8 cases and their Cho and Cho/NAA increased high again. Other cases without recurrence, HMRS showed no change. Conclusion： Multivoxel proton MR spectroscopy is available for study of tumor metabolites after radiotherapy and it is a valuable method in the evaluation of radiotherapy treated tumors,
基金
a grant from the Medical Foundation of Wu Jieping(No.32067000501).
