热化疗对口腔颌面癌患者细胞毒性T淋巴细胞活性的影响

Influence of thermochemotherapy on the activity of cytotoxic T lymphocyte in oral maxillofacial cancer patients

目的探讨热化疗对口腔颌面癌患者细胞毒性T淋巴细胞(CTL)活性的影响。方法选取21例口腔颌面癌患者接受热化疗,于第一次治疗前和最后一次治疗后取其外周血行CTL活性检测。结果热化疗后口腔颌面癌患者CTL活性较治疗前大大提高,其差异有统计学意义(P<0.01)。结论热化疗可以提高口腔颌面癌患者CTL的活性,从而增强机体的免疫功能,提高机体抗肿瘤效应。

Objective To study the influence of thermochemotherapy on the activity of cytotoxic T lymphocyte （CTL） in peripheral blood of patients with oral maxillofacial cancer. Methods Twenty-one subjects with oral maxillofacial cancer were treated by thermochemotherapy, and the activity of CTL in peripheral blood was analyzed, Results Thermochemotherapy can obviously enhance the activity of CTL （P〈0.01）. Conclusion Thermochemotherapy can enhance the activity of CTL, thus enhance the patient＇s immune function. Therefore, it can enhance the antitumor response in whole body.