口腔鳞癌患者的全血功能状态与肿瘤复发风险的相关性研究

Study on the relationship between function of blood and tumor recurrence in oral squamous cell carcinomas

目的检测口腔鳞癌患者的出、凝血功能变化,为临床诊治和预后评估提供参考。方法选择65例健康人(对照组)和351例口腔鳞癌患者(试验组)为研究对象,试验组又分为原发组、颈淋巴转移组和复发组。采用BTS-330四通道自动血凝仪检测健康人和患者的血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(Fib),用SPSS11.0软件包进行统计分析。结果对照组与试验组的血浆PT和APTT有统计学差异(P<0.05),而TT和Fib无统计学差异(P>0.05)。对照组血浆PT较颈淋巴转移组和复发组缩短(P<0.05);APTT除在颈淋巴转移组和复发组间无统计学差异外,其余各组间均有统计学差异(P<0.05)。结论PT和APTT可能对口腔鳞癌患者的临床诊治和预后评估有重要价值。

Objective To explore the coagulation indexes and offer a valuable reference for clinic therapy and prognosis in patients with oral squamous cell carcinomas （OSCCs）. Methods The indexes of prothrombin time （PT）, activated partial thromboplastin time （AFTT）, thrombin time （TT） and fibrinogen （Fib） were detected by using automatic blood coagulation testing machine in 65 healthy people and 351 patients with OSCCs. All patients with OSCCs were divided into three groups included primary tumor, neck metastasis of lymph nodes and recurrence. The data were analysed by SPSS 11.0. Results The index of PT in patients with OSCCs was longer than that of healthy people. There was a significance between the control group and the group with the neck metastasis of lymph node or the recurrence group （P〈0.01）. The time of APTT was shortened. Except for the group with the neck metastasis of lymph node and the recurrence group the distinctive difference existed in other groups （P〈0.05）. There was no significance between two groups in the indexes of TT and Fib（P〉0.05）. Conclusion PT and APTT may be the useful indexes for clinic therapy and prognosis in patients with oral squamous cell carcinomas.