精子膜蛋白研究进展

Progress in the Researches on Sperm Membrane Proteins

精子膜表面的蛋白是精子发生、成熟和精卵相互作用的重要分子,对其深入研究有助于揭示精子发生、成熟以及受精的分子机制。近年来,各种现代分子生物学技术以及生物信息学方法在生殖生物学领域的广泛应用,不仅使以前发现的一些精子膜蛋白相继得到克隆和测序,同时新的精子膜相关蛋白也不断被发现,为从基因和蛋白质水平研究其生物学功能、揭示生物生殖的分子机制并进而为避孕疫苗的开发等奠定了基础。本文就近年来精子膜蛋白的研究进展作一综述。

Sperm membrane proteins play a key role in spermatogenesis, sperm maturation and sperm-oocyte interaction. A deeper research would shed new light on the molecular mechanisms of spermatogenesis, sperm maturation and fertilization. In recent years, with the extensive application of a variety of current molecular biological methods and bioinformatics to reproductive medicine, some sperm membrane proteins found previously have been cloned and sequenced. Furthermore, new sperm membrane proteins, being found continuously, will make a solid foundation for the development of contraceptive vaccine as well as for the investigation into the mechanism of fertilization at levels of gene and protein. This article reviews the current progress in the researches on sperm membrane proteins.