摘要
目的:观察高盐摄入对自发性高血压大鼠(SHR)循环血液中内皮素-1(ET-1)及C型利钠肽(CNP)的影响。方法:将9周、28周、53周的雄性SHR做为3个不同的周龄组,每个周龄组再随机分为正常盐组和高盐组并进行编号,每组各7只,正常盐组给予饲料(含0.9%NaI),高盐组给予饲料(含4%NaI),共饲养3周,应用放射免疫分析技术检测各周龄组血浆中的ET-1及CNP的浓度。结果:无论是正常盐饮食还是高盐饮食,随着周龄的增加SHR的血压均升高,血液中CNP和ET-1水平也呈增龄性增加;在不同周龄组的SHR中,与正常盐组相比,高盐组SHR的血液中CNP降低,而ET-1水平升高。结论:盐负荷使SHR血液中CNP降低和ET-1升高可能是其血压增龄性升高的一个重要机制。
Objective; To investigate the effects of highsalt on plasma concen-trations of CNP and ET-1 in spontaneously hypertensive rats, Methods： MaleSHR were used as experimeutal animals,and they were divided into three groups ： 9-week-old （9w）, 28-week-old （28w） and 53-week-old （53w）. Each group was divided into two sub-groups randomly： normal-salt （0. 9%NaCI） diet or high-salt （4%NaCI） diet, Each sub-groups was feeded for 3 weeks before the study. Plasma concentrations of CNP and ET-1 were measured by radioimmunoassay and were compared between normal-salt diet and high-salt diet. Results：The sistolic blood pressure increased,plasma concentrations of CNP were decreased and plasma concentrations of ET-1 increased with ageing . Compared with normal-salt diet, plasma concentrations of CNP significantly increased in all three age groups with high-salt diet（P〈0, 05） ; , compared with normalsalt diet, plasma concentrations of ET-1 increased in all three age groups with high-salt diet（P〈0.05）. Conclusion： The changes of CNP and ET-1 expression may be the base of blood pressure increase with ageing in salt-sensitive SHR.
出处
《陕西医学杂志》
CAS
北大核心
2007年第8期939-942,共4页
Shaanxi Medical Journal
基金
美国中华医学基金会资助项目(项目编号:1-761)
