拉米夫定联合维生素E治疗慢性乙型肝炎临床观察

Study on the antiviral outcome of lamivudine combined with Vit E in the patients with chronic hepatitis B

目的探讨拉米夫定联合维生素E对慢性乙型肝炎患者的治疗效果。方法将120例慢性乙型肝炎患者随机分为对照组和治疗组,对照组给予拉米夫定,治疗组在对照组基础上加用维生素E,疗程6个月,比较两组治疗前后ALT、HBV DNA及HBsAg、HBeAg、HBeAb的变化。结果慢性乙型肝炎治疗组的ALT复常率、HBV DNA的转阴率与HBeAg的阴转率及HBeAb的阳转率均较对照组明显增高(P＜0．05)。结论维生素E可作为治疗慢性乙型肝炎的辅助药物。

Objective To evaluate the antiviral outcome of lamivudine combined with Vitamin E in the patients with chronic hepatitis B. Methods One hundred and twenty patients with chronic hepatitis B were classified into the control group and Vitamin E group randomly. All the patients included in the control group were given oral lamivuding with the dose of 100 mg daily for six months. Meanwhile, the other subjects were given additional Vitamin E with the dose of 01g thricely a day. Results At the end of the study period, alanine aminotransferase （ALT） normalization was observed in 54 （90%） patients in Vitamin E group and only in 45 （75%） of the controls （P〈0.01）; HBV-DNA negative conversion was observed in 48 （80%） patients in the Vitamin E group as compared to 38 （63.3%） in the control group, respectively （P〈0.01）.Compared with the 4（6.7%） in the controls, the serum negative conversion of HBeAg was found in 12 （20%） patients in the Vitamin E group. Conclusion Vitamin E supplementation might be effective in the treatment of chronic hepatitis B.