Ether à go-go钾通道与恶性肿瘤

Ether à go-go potassium channel and malignant tumors

离子通道与恶性肿瘤的研究相关性日益受到重视,其中以钾通道的研究最为深入.Etheràgo-go钾通道(Eagl)由于在体内局限性分布、具有癌基因的特性以及在多种临床肿瘤组织中高频率表达的特点,已经成为前景乐观的恶性肿瘤诊治的靶点.本文综述Eagl钾通道与细胞周期和增殖的关系、致癌性及其致癌机制、在恶性肿瘤中的表达及其意义、分子成像技术检测活体内Eagl以及Eagl作为治疗靶点的实验研究进展.

Recently, increasing evidence from cell biology and pharmacology demonstrates that cancer cells exhibit ion channel expression patterns, ion conductances and electric properties that are very different from those of resting cells. These peculiar properties are functionally involved in cancer pathogenesis. In particular, because of its oncogenic properties, distribution, modulation and pharmacology, human ether a go-go potassium channel （Eagl, Kvl0.1, KCNH1） is considered a critical ion channel-encoding gene involved in the establishment ＇ and maintenance of neoplastic growth. This review summarizes most of the findings regarding Eagl channels and malignant tumors, focusing on cellular mechanisms, mRNA and protein expression in tissues, oncogenic properties, modulation and pharmacology.