大鼠受体性别对肝移植效果的影响

Influence of recipient gender on outcome of liver transplantation in rats

目的探讨大鼠性别对肝移植效果的影响。方法根据大鼠受体性别将实验动物分为2组：雄性（M）组和雌性（F）组，比较两组术后急性排斥反应（ACR）发生率、术后7d肝功及术后6周生存率。结果F组大鼠肝移植效果优于M组，两组术后急性排斥反应的发生率、术后7d ALT及AKP水平、术后6周生存率具有显著性差异（P〈0．05或0．01）。结论性别对大鼠肝移植的急性排斥反应、生存率及术后肝功能的恢复有重要的影响。

Objective To investigate the effects of recipient gender on outcome of liver transplantation in rats. Methods The animals were divided into 2 groups based on the recipient gender. The 6-week survival rate, incidence of acute rejection and 7-d liver functional index were determined in both groups after liver transplantation. Results The effect of liver transplantation is better in female group than in male one. The incidence of acute rejection and levels of ALT and AKP were markedly lower in female group than in male group （P〈0.05 or 0. 01）. The 6-week survival rate was remarkably higher in female group than in male group （P〈0.05）. Conclusion Gender can significantly influence acute rejection, survival rate and liver functional recovery in rats after liver transplantation.