摘要
自分泌运动因子受体(autocrine motility factor receptor,AMFR)属于泛素蛋白酶体系统蛋白,其配体除自分泌运动因子(autocrine motility factor,AMF)外还包括神经白细胞素(neuroleukin,NLK)、磷酸己糖异构酶(phospho-hexose isomerase,PHI)和成熟因子(maturation factor,MF)等。AMFR及其配体系统具有广泛的功能,如刺激细胞运动,作为神经营养因子营养及保护神经元,调节能量代谢和介导细胞的分化等。本文主要就AMFR及其配体系统的结构特点及在肿瘤及神经系统中作用的研究进展作一综述。
Autocrine motility factor receptor （AMFR） belongs to the ubiquitin-proteasomes system, one of the major intracellular proteolytic systems. Besides autocrine motility factor （AMF）, neuroleukin （NLK）, phosphohexose isomerase （PHI） and maturation factor （MF） are also ligands of AMFR. Thus the AMFR and its ligands system can provide extensive functions, such as inducing cell motile activity, providing general neuroprotective effect, modulating energy metabolism and mediating differentiation of human myeloid leukemia cells. This article mainly reviews the structural features of AMFR and its ligands and biological function in tumor and the nervous system.
出处
《军事医学科学院院刊》
CSCD
北大核心
2007年第5期474-477,共4页
Bulletin of the Academy of Military Medical Sciences
基金
国家重点基础研究发展规划("973")项目(2004CB518907)
国家自然科学基金项目(30600670
90709012
30772562)
