生物活性修复材料—康倍治疗烧伤的疗效观察

STUDY ON EFFICACY AND SAFETY OF BIOACTIVE MATERIAL——COMBEST IN TREATING BURN

目的观察生物活性玻璃和透明质酸钠结合修复材料(康倍)治疗烧伤创面的疗效。方法2006年3月～9月,收治烧伤患者20例,其中男16例,女4例;年龄18～58岁,平均40岁。创面类型:深度烧伤创面7例,度烧伤残余肉芽创面9例,植皮后皮间隙4例。按随机、同体对照原则,试验组与对照组各20个创面,创面范围2.0cm×1.5cm～40.0cm×20.0cm。试验组创面以康倍换药,对照组以空白膏剂换药。分别于用药后1、3、6、11、16及21d观察各创面的肉芽生长和愈合情况,并检查用药前后肝、肾功能及血常规。结果试验组创面用药后11d愈合3例,16d愈合4例,21d愈合4例;对照组创面观察期无完全愈合者。观察期内愈合面积达2/3以上者试验组18例,对照组为1例。按照创面愈合评价标准,试验组显效18例,有效1例,可疑有效1例,总有效率为95%;对照组显效1例,有效9例,可疑有效10例,总有效率为50%,试验组疗效明显优于对照组(P<0.01)。患者治疗前后血常规及肝、肾功能等指标无明显异常改变。结论康倍具有良好促进肉芽生长、加快创面愈合的作用。

Objective To explore the efficacy and safety of bioactive material（combest） which is combinated with bioglass and hyaluronan on burn wound healing. Methods From March to September 2006,＇ 20 patients were treated; including 16 males and 4 females, aging 18-58 years （40 years on average）. The wounds were classified as deep degrees Ⅱin 7 cases, granulated wounds in 9 cases and graft site wounds in 4 cases. Twenty wounds in one side were repaired with Combest as the test group and 20 wounds in the other side with blank cream as the control group. The wounds in size ranged from 2.0 cm × 1.5 cm to 40.0 cm × 20.0 cm. The wound healing rate was observed, and the blood test and the indices of hepatic and renal function were determined on the 1st, 3 rd, 6 th, 11 th, 16 th and 21 st days of treatment. Results Wound healed within 3 weeks in 11 cases of the test group （3 cases on the 11 st day, 4 on the 16 th day, and 4 on the 21 st day） , but no wound healing was observed within 3 weeks in the control group. The healing size accounted for 2/3 of wounds in 18 cases of the test group and in 1 case of the control group. The excellent and good rates were 95%（18 cases and 1 case） in the test group and 50% （1 case and 9 cases） in the control group, showing significant difference （P〈0. 01）. For all patients, no obvious changes were found in the blood test and hepatic or renal function indices. Conclusion Combest combinated with bioglass and hyaluronan is beneficial to the proliferation of the granulation and wound healing with good safety.