大肠癌患者生命质量测定量表FACT-C(V4.0)中文版应用评价

Evaluation of the Functional Assessment of Cancer Therapy-Colorectal (V4.0) in Chinese version

目的:对大肠癌患者生命质量测定量表FACT-C(V4.0)中文版的应用效果进行考评。方法:①选择2001/2005云南省肿瘤医院收治的具有一定文化程度(文盲及看不懂量表者除外)的大肠癌住院患者作为调查对象。②调查者以医生的身份出现,作简单的解释和说明后将FACT-C中文版量表发给110例知情同意的患者填写,并等待其完成后收回检查有无漏项。对每个调查对象在入院时进行一次测定,并抽取109例患者在第2～3天进行一次重测,经过治疗后在出院前再抽取54例患者进行第3次测定。③按照FACT-C的计分规则计算各条目、领域和总量表得分,并据此计算各种信度、效度、反应度指标。结果:①信度:各个领域的重测相关系数均在0.76以上;各领域内部一致性信度的α值除附加关注领域为0.56外,其余均在0.80以上。②效度:各条目与其所属领域的相关系数较大,而与其他领域的相关较小;对共性模块FACT-G的27个条目进行因子分析,提取了4个主成分,累积方差贡献达到70.03%。③反应度:生理状况、附加关注、试验结局指数及总量表得分均显示治疗前后差异有统计学意义。结论:FACT-C中文版具有较好的信度、效度及反应度,可作为我国大肠癌患者生命质量的测评工具。

AIM： To evaluate the efficacy of Functional Assessment of Cancer Therapy-Colorectal （FACT-C, V4.0） in Chinese version. METHODS： （1）Inpatients with colorectal cancer who hospitalized at the Yunnan Provincial Tumor Hospital with certain education background （excluding illiteracy and those who cannot read the questionnaire） were selected from 2001 to 2005 as subjects. （2）The investigators （doctors or appeared as doctors） explained the purpose of the survey and scale before distributing the Chinese FACT-C questionnaire to those patients （110 cases） who agreed to participate in the study. The completed questionnaires were checked immediately for confirmation of no missing items. Each subject was initially assessed at admission. A sub-sample of 109 patients underwent a second assessment the next day or the second day after hospitalization. And 54 patients were assessed a third time at their discharge after treatment. According to scoring methods of FACT-C, the scores of items, domains and overall scale were calculated to compute the indicators of reliability, validity and responsiveness. RESULLTS： （1）Reliability： The correlation coefficients for 5 domains were all above 0.76; internal consistency α for each domain was higher than 0.80 except that the additional concern was 0.56. （2）Validity： There were strong correlations between items and their own domains and weak correlations between items and other domains; 4 common factors were abstracted from 27 items of general model FACT-G, and the cumulative contribution rate was 70.03%. Responsiveness： There were significant differences in physical well-being, additional concerns, trial outcome index and total scores between pre-treatment and post-treatment. CONCLUSION： The FACT-C （V4.0） in Chinese version is of reasonable validity, reliability and responsiveness. It can be used to assess the quality of life for patients with colorectal cancer.