百忧解与多虑平治疗脑卒中后抑郁的对照研究

A Controlled Study of Prozac and Doxepin in Treatment of Post-stroke Depression

目的比较百忧解与多虑平对脑卒中后抑郁的治疗效果。方法100例首发脑卒中后伴有抑郁的患者随机分为2组,分别给予百忧解和多虑平进行治疗,于治疗前后用汉密顿抑郁量表(HAMD)及治疗药物副反应量表(TESS)作检测。结果百忧解对脑卒中后抑郁的总有效率为94%,HAMD评分下降速度百忧解明显快于多虑平,副作用百忧解明显少于多虑平。结论百忧解治疗脑卒中后抑郁有效率高,较多虑平疗效快,副作用少。

Objective To evaluate the therapeutic effects of prozac compared with doxepin in treatment of post stroke depression. Methods One hundred consecutive depressed patients entered this trial 17 days after stroke, and they were randomly divided into prozac group and doxepin group. Treatment was given for a period of 6 weeks. Patients were assessed before and after treatment by HAMD and TESS. Results The total rate of curative effect in releasing post stroke depression is 94% in prozac group. Prozac produced a statistically significant reduction of HAMD and was more quickly than doxepin. The side effect of prozac was fewer and milder than doxepin. Conclusions Prozac in treatment of post - stroke depression has high efficacy and few side effects.