Mcl-1和Survivin在B细胞非霍奇金淋巴瘤中的表达及意义

Expression and clinical significance of Mcl-1 and Survivin in B cell non-Hodgkin＇s lymphoma

目的探讨Mcl-1和Survivin在B细胞非霍奇金淋巴瘤（B-NHL）中的表达及临床意义。方法采用免疫组化SP法检测43例B-NHL和10例良性淋巴结病变组织中Mcl-1和Survivin的表达。结果Mcl-1和Survivin在B-NHL中的阳性表达率分别为65.1%（28/43）和69.8%（30/43）,与对照组相比差异有统计学意义（P〈0.05）。侵袭性B-NHL患者Mcl-1的表达要高于惰性组（P〈0.05）,Survivin的表达与B-NHL的组织病理学等级和国际预后指数（IPI）具有相关性（P〈0.05）。Spearman相关分析表明Mcl-1的表达与Survivin的表达呈正相关（r=0.47,P〈0.01）。结论Mcl-1和Survivin在B-NHL中表达上调以及两者之间的阳性表达密切相关,表明Mcl-1和Survivin在B-NHL的发生和发展中具有协同作用。

Objective To investigate the expression and clinical significance of Mcl-1 （myeloid cell leukemia-1, Mcl-1 ） and Survivin in B-NHL（ B cell non-Hodgkin＇s lymphoma, B-NHL）. Methods The expression of Mcl-1 and Survivin in 43 cases of B-NHL and 10 cases of benign lymph node lesions were detected by immunohistochemical streptavidin - biotin peroxidase method. Results The expression rate of Mcl-1 and Survivin in B-NHL was 65.1% （28/43） and 69.8% （30/43） respectively. Compared with the control, there was a significantly statistic difference （ P 〈0.05 or P 〈0. 01 ）. The expression of Mcl-1 in patients with aggressive B-NHL was higher than that of patients with indolent B-NHL（ P 〈 0. 05 ）. The expression of Survivin was related with histopathologic grade and IPI of B-NHL（ P 〈 0. 05 ）. Spearman＇s correlation analysis showed that Mcl-1 expression was positively correlated with Survivin expression （ r = 0. 474, P = 0. 001 ）. Conclusion The specific up - regulation of Mcl-1 and Survivin in B-NHL and the positive correlation between expression of Mcl-1 and Survivin showed that they had a synergistic effect in the development and progression of B-NHL.