反复呼吸道感染患儿免疫球蛋白及相关细胞因子水平分析

A Study of Level of Immunoglobulin and Cytokine in Children with Recurrent Rrespiratory Tract Infections

目的观察反复呼吸道感染(RRTI)患儿的相关免疫功能的改变。方法选择符合RRTI诊断标准的患儿(患儿组)和健康儿(对照组),分别检测RRTI患儿治疗前(病程初期)、治疗后(恢复期)及健康儿的免疫球蛋白IgGI、gAI、gM水平和细胞因子干扰素-γ(IFN-γ)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)水平,并进行比较。结果RRTI患儿治疗前后的血清IgG水平显著低于对照组(P<0.01或P<0.05),治疗后的IgG水平明显高于治疗前(P<0.01);RRTI患儿治疗前血清IgA水平显著低于治疗后和对照组(P<0.01);RRTI患儿治疗前后的血清IgM水平无明显变化(P>0.05)。RRTI患儿治疗前血清IFN-γ和IL-10水平显著低于对照组(P<0.01),治疗后IFN-γ水平明显低于对照组(P<0.05),治疗后IL-10水平有所回升;RRTI患儿血清IL-6水平治疗前高于治疗后,但均高于对照组(P<0.01)。结论RRTI患儿机体的体液和细胞免疫存在着不同程度的功能缺陷。

Objective To explore immunologic changes of children with recurrent respiratory tract infections（RRTI）.Methods RRTI children According to the claim and normal children were selected as the case group and control group respectively.Serum immunoglobulin IgA,IgG,IgM,cytokine interferon-γ（IFN-γ）,interleukin-10（IL-10） and interleukin-6（IL-6） of RRTI children were monitored before and after treatment,and compared with controlt group.Results IgG of case group before and after treatment were significantly lower than that of normal children（P〈0.01,P〈0.05）.IgG in cases after treatment was higher than that before treatment（P〈0.01）.Before treatment,IgA of case group was much lower than control group（P〈0.01）.IgA of cases after treatment was higher than that before treatment（P〈0.01）.There were no difference between RRTI before and after treatment in IgM（P〉 0.05）.Before treatment,IFN-γ and IL-10 of case group were lower than that of control group（P〈0.01）.after treatment both indexes increased significantly but still lower than control group（P〈0.05）.IL-6 in RRTI before and after treatment were much higher than that in control group（P〈0.01）.after treatment IL-6 was lower than that before treatment（P〈0.01）.Conclusion There are different deficiency of humoral immunity and cellular immunity in RRTI children.So it is important to evaluate immune state of RRTI children timely for regulating immune system.