p73和Ki-67在口腔扁平苔藓及口腔鳞状细胞癌中的表达及意义

Significances of p73 and Ki-67 Expression in Oral Squamous Cell Carcinoma and Lichen Planus

目的探讨p73、Ki-67在口腔扁平苔藓和口腔鳞状细胞癌中的表达及其意义。方法以正常口腔黏膜作为对照,采用免疫组化方法,检测30例口腔扁平苔藓组织、62例口腔鳞状细胞癌组织中p73、Ki-67的表达情况,采用美国专业图像分析软件进行累计光密度值(IOD)的测量。结果p73、Ki-67的阳性表达从正常口腔黏膜到口腔扁平苔藓再到口腔鳞状细胞癌这一过程中均呈逐渐增高的趋势,各组间IOD值的差异均有统计学意义(P<0.05),而且p73、Ki-67表达的IOD值强度与癌组织的分化程度相关。p73、Ki-67在口腔扁平苔藓、正常口腔黏膜、口腔鳞状细胞癌组织中的表达呈正相关(P<0.05)。结论p73、Ki-67在口腔鳞状细胞癌的发生发展中起着一定作用,这两个指标可作为诊断口腔扁平苔藓癌变的标记物之一。

Objective To investigate the significance of p73 and Ki-67 in oral lichen planus and oral squamous cell carcinoma.Methods The expression of P73 and Ki-67 was detected by immunihistochemisty in 30 cases of oral lichen planus、62 cases of oral squamous cell carcinoma and 30 cases of normal oral tissue.The results were analyzed with the software of Image Plus 5.0.Results The expression of p73 and Ki-67 increased significantly as the progression of oral mucosa from normal to oral lichen planus and oral SCC.The intensity of p73 and Ki-67 expression correlated with histological grade.The expression of p73 and Ki-67 in normal oral mucosa,oral lichen planus,oral SCC were significantly correlated（P〈0.05）.Conclusion p73 and Ki-67 may play important roles in developing course of oral squamous cell carcinoma.