摘要
目的:探讨乳腺癌患者细胞免疫状态与预后危险因素之间的关系。方法:回顾性分析1997年至2002年收治的110例女性乳腺癌患者的临床资料,分析其一般情况及CD3+T、CD4+T、CD8+T、CD4+/CD8+、淋巴细胞转化率(LTR)的变化及其与乳腺癌肿块大小、淋巴结转移情况及癌胚抗原(CEA)的关系。结果:①乳腺癌不同肿块大小患者中CD4+T、CD8+T、CD4+/CD8+水平差异有统计学意义(P<0.01或P<0.05),在肿块较小时即有CD4+T水平的降低和CD8+T水平的升高,而CD4+/CD8+水平随着肿瘤负荷的增大而降低;②淋巴结转移组[LN(+)]与未转移组[LN(-)]比较,CD4+/CD8+在LN(+)组中显著降低(P<0.05);CD3+T、CD4+T、CD8+T在LN(+)组中表达增高,CD3+T、CD8+T的升高有统计学意义(P<0.05或P<0.01)。③CEA在LN(+)组中明显升高(P<0.05),在不同肿瘤负荷组间比较差异无统计学意义(P>0.05)。CEA(+)组和CEA(-)组之间比较,CD4+T升高及CD4+/CD8+水平降低差异均有统计学意义(P<0.01),且CEA与CD4+T及CD4+/CD8+水平密切相关(P<0.01)。结论:乳腺癌患者存在不同程度的细胞免疫状态紊乱,且与乳腺癌CEA水平及肿块大小、淋巴结转移情况密切相关。
Objective: To investigate the cytoimmunologic status of patients with breast cancer and its relationship with prognostic risk factors. Methods: One hundred and ten patients with breast cancer in Shandong Provincial Hospital between 1997 and 2002 were retrospectively analyzed. Clinical features, as well as the alternation of CD3^+ T, CD4 T, CDs T, CD4/CDs and LTR and their relationship with mass size, metastasis of lymph nodes and CEA were also analyzed. Results: ①There were statistical differences in the percentage of CD4 T and CDs T and the ratio of CD4/CDs between groups of different mass sizes ( P 〈 0.05 or P 〈 0.01 ). The percentage of CD4 T was decreased and of CDs T was increased when mass size was small. The ratio of CD4^+/CD8^+ went down with an increase of mass size. ②Percentages of CD3^+ T and CDs T in patients with metastasis of axillary lymph nodes[ LN( + ) ] were significant higher than those without metastasis of axillary lymph nodes [LN( - ) ] ( P 〈 0.05 or P 〈 0.01). The of CD4^+/CD8^+ was significant lower ratioin patients with metastasis of LN( + ) than those without metastasis of LN( - ) ( P 〈 0.05 or P 〈 0.01 ). The percentage of CD4+ T was higher in patients with metastasis of LN( + )than in patients without metastasis of LN( - ), but no significant difference was found(P 〉 0.05). ③The CEA level was significant higher in patients with metastasis of LN ( + ) than in patients without metastasis of LN( - ) (P 〈 0.05), and no such difference was shown between different mass-size groups(P 〉 0.05). The increase of CD4^+ T percentage and the decrease of CD4^+/CD8^+ ratio were obvious in the CEA( + ) group compared with the CEA( - ) group( P 〈 0.01), and CEA was significantly correlated with the CD4^+ T percentage and the CD4^+/CD8^+ ratio ( P 〈 0.01 ). Conclusion: Disorder of the cytoimmunologic situation exists in patients with breast cancer, and it is closely correlated with the highly prognostic factors of mass size and the metastasis sit- uation of axillary lymph nodes.
出处
《山东大学学报(医学版)》
CAS
北大核心
2007年第9期934-937,共4页
Journal of Shandong University:Health Sciences
关键词
乳腺肿瘤
细胞免疫
T细胞亚群
癌胚抗原
Breast neoplasm
Cytoimmunity
T-lymphocyte subsets
Carcinoembryonic antigen