三维治疗计划系统的临床剂量学验证

Clinical dosimetry verification for 3-D treatment planning system

目的 对HW—Plan V1．0三维治疗计划系统进行临床剂量学验证，以检验HW—Plan系统在临床正常使用条件下的有效性和安全性。方法使用HW—Plan三维治疗计划系统对50例典型的临床病例做治疗计划，以检验其各项功能的实现情况，验证该计划软件对不同病例的处理能力，并把HW—Plan和医院参考治疗计划系统计算的放疗计划结果、三维剂量场分布数据进行比较。结果HW—Plan三维治疗计划系统能够实现肿瘤适形放射治疗计划设计所需要的各项功能；成功完成临床各病例的治疗计划设计；同医院参考治疗计划系统比较中：设置相同的照射技术和射野权重，MU计算差异在5％以内的占97．4％；输入相同的MU，计算等中心剂量差异在5％内的占98．0％；90％等剂量线之间距离平均值〈1mm；90％等剂量线包围的面积差异平均值为-3．1％。结论验证结果证明，HW—Plan三维治疗计划系统具有在临床正常使用条件下预期的有效性和安全性。

Objective To investigate the safety and validity of HW-Plan V1.0 3-D Conformal Treatment Planning System（TPS）. Methods Typical clinical tumor cases were used to check all its functions and verify its capability to deal with various clinical cases. Comparisons were carried out between the results finished by HW-Plan TPS and commercial TPS used in the hospital, including 3-D dose distributions. Results All the functions for 3-D conformal radiotherapy of tumor were realized by HW-Plan TPS, and all the radiotherapy plan for clinical cases were successfully finished. In the comparisons between reference TPS, differences of Monitor Unit for 97.4% of all the field of beams were within 5% ; under same beam arrangement, the differences of dose at isocenter for 98.0% of all the cases were within 5%; mean distances of 90% isodose lines was 〈 1 mm; mean differences of area in 90 % isodose lines was - 3.1% . Conclusions HW-Plan TPS was proved to be qualified for clinical implementation with enough safety and validity.