舒芬太尼用于无痛结肠镜检查的临床观察

The Observation of Sufentanil for Outpatient Colonoscopy

目的研究舒芬太尼用于无痛结肠镜检查的安全性和可行性。方法80例结肠镜检查患者,随机分为两组(n=40):舒芬太尼复合咪唑安定组(S组)和芬太尼复合丙泊酚组(F组)。术中监测BP、HR、SpO2、RR,有无体动和呼吸暂停和麻醉后离院评分达标(TMPADSS)时间。结果术中SBP、HR、SpO2、RR与术前比较均有不同程度地下降(P<0.05,P<0.01),与S组比较,F组SBP降低更明显(P<0.05),S组患者TMPADSS明显短于F组(P<0.01),术中体动反应发生率低于F组(P<0.05)。结论舒芬太尼可以安全用于门诊无痛结肠镜检查术。

Objective To investigate the safety and feasibility of the total intravenous anesthesia with sufentanil for outpatient colonoscopy. Methods eighty patients undergoing colonoscopy were randomized into group S （ n = 40） and group F （ control group n=40） . All patients in group S were given midazolam 0.04 mg/kg and sufentanil 0.1μg/kg, All patients in group F were administrated fentanyl 1 ug/kg and propofol 2mg/kg. BP, HR, SpO2, RR, Body action and TMPADSS were detected. Results there were no significant differences in the SBP, HR, RR and SpO2 before the colonoscopy,the above - mentioned items in the colonoscopy were decreased obviously （P 〈0. 05,P 〈0. 01） . When group F was compared with group S,SBP and the inci- dence of body action was lower P 〈0.05） , TMPADSS was shorter（P 〈0.01 ）. Conclusion The total intravenous anesthesia with sufentanil is safe and feasible for outpatient colonoscopy.