CEA、FER、β_2-MG、ET检测在肺癌诊断中的应用价值

Clinical Application of CEA,FER,ET and β_2-MG in the Diagnosis of Lung Cancer

目的探讨癌胚抗原(CEA)、铁蛋白(FER)、内皮素(ET)、β2-微球蛋白(β2-MG)等肿瘤标志物的检测在基层医院肺癌诊断中的临床意义。方法应用放射免疫检测方法对肺癌组和对照组患者血清中标志物含量进行检测。结果肺癌组4种标志物水平明显高于对照组,具有显著性差异。其中单一标志物检测CEA对腺癌的检出率最高,达到70%。联合检测可使肺癌确诊率大大提高,尤其FER、CEA和ET联合组对腺癌的确诊率可达92%。结论这些标志物在基层医院肺癌的诊断中仍有重要的临床应用价值。

Objective To evaluate the clinic significance of nonspecific serum tumor markers such as carcinoembryon ic antigen （CEA）, ferritin （ FER）, endostatin （ET） and （ 2 - microglobuli n （β 2 -MG） in diagnose of lung cancer in primary hospital. Methods The serum levels of these tumor markers were measured by immunoradioassay. Results The markers in lung cancer group was obviously higher than that in control group and there was significant difference. The posi- tive rate of CEA was the highest in adenocarcinoma （70%）. Combination method could elevate the accurate rate,especially the accurate rate of FER,CEA, ET unite was 92% in adenocarcinoma. Conclusion The tumor markers have very important clinical application value in diagnose of lung cancer in primary hospital.