药物遗传学在法医学中的应用前景

The Prospect of Application of Toxicogenetics/Pharmcogenetics Theory and Methods in Forensic Practice

人类因为基因的差异而表现出对某种药物、毒物、外界有害的化学物质、过敏原作出不同的反应。这种遗传背景的差异使一些人可以快速地清除这些物质,而另一些人却因此产生严重的不良反应,甚至死亡。药物遗传学和药物基因组学,通过对人类基因组测序和大规模基因组多态性的鉴别研究,诠释了个体遗传差异与对药物毒物不同反应之间的关系,这为该类案件的法医学鉴定提供了新的理论基础和研究手段。

Individual response to drugs, toxicants, environmental chemicals and allergens varies with genotype. Some respond well to these substances without significant consequences, while others may respond strongly with severe consequences and even death. Toxicogenetics and toxicogenomics as well as pharmacogenetics explain the genetic basis for the variations of individual response to toxicants by sequencing the human genome and large-scale identification of genome polymorphism. The new disciplines will provide a new route for forensic specialists to determine the cause of death.