布地奈德悬液和硫酸特布他林联合雾化阶梯治疗毛细支气管炎

Effects of atomizing inhalation of nebulized budesonide suspension combined with terbutaline sulfate solution on capillary bronchitis

目的探讨布地奈德悬液和硫酸特布他林联合雾化吸入阶梯治疗毛细支气管炎的疗效。方法将57例毛细支气管炎患儿随机分为对照组和治疗组。两组的综合治疗相同。治疗组:布地奈德悬液0.25 mg,0.5%硫酸特布他林0.5 ml混合液序贯,阶梯治疗即2 h 1次,连用2次后改为8 h 1次,连用1 d,然后每12 h一次,连用2 d,最后1次/d,连用3 d;对照组每次用药剂量相同,2次/d,雾化吸入,总疗程均为7 d。对两组治疗前后症状,体征的消失时间,住院费用,住院天数进行比较分析。结果治疗组在缓解喘憋,咳嗽,肺部喘鸣,湿口罗音消退时间,住院费用,住院天数均优于对照组(P<0.05)。结论布地奈德悬液,硫酸特布他林联合治疗毛细支气管炎疗效显著。阶梯治疗可以提高疗效,减少费用,病人依从性好,值得临床推广。

Objective To investigate the clinical effects of atomizing inhalation of nebulized budesonide suspension combined with terbutaline sulfate solution on capillary bronchitis.Methods Fifty-seven patients with capillary bronchitis were randomly divided into two groups： treatment group（n=27） and control group（n=30）.Based on the same synthetic therapy,the patients in treatment group were given inhaled 0.25 mg nebulized budesonide suspension combined with 0.5 ml 0.5% terbutaline sulfate solution for step-treatment： once 2 h for 2 times,once 8 h for 1 d,once 12 h for 2 d,once a day for 3 d;while in control group,the patients were given twice a day for 7 d.The symptoms and physical signs in lung,hospitalization days,costs were analyzed and compared between two groups.Results The symptoms and physical signs in lung were relived.There was significant difference between 2 groups.The hospitalization days and costs were less in treatment group than in control group（P〈0.05）.Conclusion The atomizing inhalation of nebulized budesonide suspension combined with terbutaline sulfate solution has synergetic effects on capillary bronchitis,which could enhance the curative effect,alleviate the symptom,shorten the course of diseases.The step-treatment is safe,simple and cheaper.