肝脏转运蛋白在药物肝胆转运中的作用

Important application of hepatic transporters on drug transport in liver and gall

目的对肝脏转运蛋白在药物肝胆转运中的作用作一综述,为药物肝靶向提供依据。方法根据文献,从药物不良反应、药物的矢量转运、药物肝靶向性、药物之间相互作用4个方面阐述肝脏转运蛋白对药物肝胆排泄产生的影响。结果肝脏转运蛋白引起的药物矢量转运影响药物的肝脏摄取,药物肝靶向性影响药物的疗效,药物之间相互作用影响临床用药安全和不良反应。结论肝脏转运蛋白在药物肝胆转运中起到了重要的作用,它与药物在体内各组织分布、临床疗效均有密切的联系。

Objective To review the application of hepatic transporters on drug transport in liver and gall. Methods Based on the literatures, the important influence of hepatic transporters on drug absorption was discussed from four aspects：adverse drug responses, vectorial transport of drugs, hepatic target of drugs and drug-drug interactions. Results Hepatic transporters could influence drug therapeutic and adverse responses, and provide a good way for hepatic targeting. Conclusions Hepatic transporters have important effects on drug transport in liver and gall, and closely associate with drug distribution in vivo and clinical treatment.