超声波辐射相转移催化合成苄基-2-萘基醚

Synthesis of Benzyl-2-Naphthyl Ether Under Ultrasound Irradiation

为了探索香料苄基-2-萘基醚的合成方法,通过对催化剂的改进和利用超声波技术改善催化条件,使苄基-2-萘基醚的合成过程向绿色化靠近.具体实验方法是,以四丁基溴化铵为相转移催化剂,环己烷为溶剂,在超声波辐射下,采用L9（3^4）正交试验法进行苄基-2-萘基醚合成条件的优化.实验结果表明,在超声波条件下,以四丁基溴化铵为相转移催化剂是合成苄基-2-萘基醚的一种可行工艺.合成苄基-2-萘基醚的最佳条件为：以四丁基溴化铵为相转移催化剂,2-萘酚与氯化苄的摩尔比为1∶1.05,反应温度为60-70℃,反应时间为1.5h,产率可达40.5%.

In order process of benzyl to -2 study the synthetic method of benzyl - 2 - naphthyl ether, we used in the synthetic naphthyl ether ultrasonic catalysis, Bu4 N^＋ Br^- as phase transfer catalyst and cy clohexane as an impregnant. In addition, we made L9 （34） orthogonal experiment to optimize reaction condition. Under the ultrasonic condition, using Bu4N^＋ Br^- as phase transfer catalyst in the synthetic process of benzyl - 2 - naphthyl ether is a kind of good industrial process. By using the ultrasonic technology, the optimal condition of syntheses of benzyl -2 -naphthyl ether using gu4 N^＋ Br^- as phase transfer catalyst, the rate of mole of 2- naphthol and benzyl chloride is 1 ： 1.05,the reaction temperature is about 60-70℃ ,and the reaction time is about 1.5h, the yield can reach over 40.5%.