高氧液对矽肺家兔红细胞免疫功能的影响

Effect of hyper-oxygenated solution on immune function of red blood cells in silicosis rabbits

目的:研究高氧液对实验矽肺家兔红细胞免疫功能的影响.方法:采用非暴露式气管注入法复制家兔矽肺模型;实验分为空白对照组、染尘对照组和染尘+高氧液组,光镜下观察各组肺组织病理改变,并比较各组间家兔红细胞受体花环率及免疫复合物花环率.结果:高氧液能显著提高染尘家兔红细胞受体花环率、降低免疫复合物花环率,并减轻染尘矽肺的病理学改变.结论:高氧液能提高实验性矽肺家兔红细胞免疫功能,可延缓或抑制矽肺病变的发展,具有一定的临床应用价值.

AIM ： To explore the effect of hyper-oxygenated solution （HOS） on immune function of red blood cells in silicosis rabbits. METHODS： The silicosis rabbit models were prepared by injection of non-exposure bronchus, and then the rabbits were divided randomly into 3 groups, control group, silica group and silica ＋ HOS group. Pathological changes of lung were observed under light microscopy, and red blood cell C3b receptor rosette rate （RCR） and immune complex rosette rate （ICR） were determined. RESULTS： Compared with the silica group, pathological changes of lung were ameliorated, RCR was significantly higher and ICR was lower in silica ＋ HOS group. CONCLUSION： HOS can enhance immune function of red blood cell in silicosis rabbits and partly restrain the development of silicosis.