还原型谷胱甘肽预防奥沙利铂神经毒性疗效观察被引量：7

Observation on preventive effect of reduced glutathione on oxaliplatin-induced neurotoxicity

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摘要目的观察还原型谷胱甘肽预防奥沙利铂神经毒性的疗效。方法对87例应用奥沙利铂全身化疗的癌症患者随机分为二组,治疗组44例,对照组43例。治疗组奥沙利铂全身化疗前2d开始使用还原型谷胱甘肽1800mg加入5%葡萄糖注射液250ml中静脉滴注,每日一次,连用7d。对照组不用还原型谷胱甘肽,其它用药与治疗组相同。观察神经系统不良反应。结果治疗组奥沙利铂神经毒性发生率11.36%(5/44),对照组为51.16%(22/43),治疗组与对照组比较,差异有统计意义(χ2=16.09,P<0.05)。结论用还原型谷胱甘肽预防奥沙利铂神经毒性疗效确切。 Objective To observe the efficacy of reduced glutathione in preventing neurotoxicity of oxaliplatin. Methods Eighty seven chemotherapy patients with oxaliplatin were randomly divided into two groups ： the treatment group （44 cases with reduced glutathione）and the control group（43 cases without reduced glutathione）. Two days before chemotherapy, the treatment group received 250 ml 5% glucose injection added with 1800 mg reduced glutathione intravenously every day for 7 days. Control group only received common treatments without reduced glutathione. Neurotoxicity of oxaliplatin was observed. Results The generation rates of neurotoxicity in two groups were 11. 36% （5/44）, 51. 16% （22/ 43） ,and had significant difference （χ^2 = 16.09, P 〈 0.05）. Conclusions Reduced glutathione is effective in preventing neurotoxicty of oxaliplatin in chemotherathy patients.

作者李海金董良李英

机构地区中国医学大学绍兴华宇医院肿瘤内科

出处《全科医学临床与教育》 2007年第5期387-388,398,共3页 Clinical Education of General Practice

关键词还原型谷胱甘肽奥沙利铂神经毒性预防 reduced glutathione oxaliplatin neurotoxicity prevention

分类号 R730.5 [医药卫生—肿瘤]

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1[1]Levi F,Misset JL,Brienza S,et al.A chronopharmacologic phase Ⅱ Clinical trial with 5-fluorouracil,folinic acid,and oxaliplatin using an ambulalory multichannel programmable pump.Highantitumor effectiveness against metastatic colorectal cancer[J].Cancer,1992,69(4):893-900.
2[2]Adelsberger H,Quasthoff S,Grosskreutz J,et al.The chemothera-peutic oxaliplatin alters voltage-gated Na + channel kinetics on rat sensory neurons[J].Eur J Pharmacol,2000,406(1):25-32.
3[3]Cavaletti G,Tredici G,petruccioli MG,et al.Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat[J].Eur J Cancer,2001,37(18):2457-2463.
4[4]Cats A.New developments in systemic clemotherapy in advanced colorectal cancer[J].Scand J Gastroenterol Suppl,2003,239(38):78-86.
5[5]Park SA,Choi KS,Bang JH,et al.Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants theough suppression of cisplatin-mediated accumulation of p53 but not of Fas/Fas ligand[J].J Neurochem,2000,75(3):946-953.
6[6]Cascinu S,Catalano V,Cordella L,et al.Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer:a randomized,double-blind,placebo-controlled trial[J].J Clin oncol,2002,20(16):478-483.