期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

受体介导长循环脂质体的制备及其研究进展 被引量：2

Ligand-grafted Long Circulation Liposome and Nuclear Medicine
下载PDF
导出
摘要 受体介导长循环脂质体,具有延长脂质体在血液循环中的半衰期、提高其稳定性、改变脂质体在体内的生物学分布,赋予脂质体主动靶向性的优点。本文主要综述了受体介导长循环脂质体的制备、研究进展及其在核医学中的应用。 Ligand-grafted long circulation liposome is an advanced and effective carrier in which drugs are modified to be stabilized in the body and delivered properly in time and amount at targeted organs with suppressing side effects.
作者 马超 匡安仁
机构地区 四川大学华西医院核医学科
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2007年第5期1200-1204,共5页 Journal of Biomedical Engineering
关键词 长循环脂质体 受体 配体 靶向性 Long circulation liposome Receptor Ligand Targeting property
分类号 R94 [医药卫生—药剂学]
  • 相关文献

参考文献20

  • 1KynclovaE,ElsnerE,KopfA,et al.Novel method for coupling of poly(ethyleneglycol) to carboxylic acid moieties of proteins.J Mol Recognit,1996; 9(5-6):644
  • 2Sapra P,Moase EH,Ma J,et al.Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab' fragments.Clin Cancer Res,2004;10(3):1100
  • 3李占山,周瑞华,周冀平,王莉莉.RGD多肽结合型长循环脂质体的肿瘤靶向性研究[J].中国药房,2003,14(7):393-394. 被引量：10
  • 4Schiffelers RM,Koning GA,ten Hagen TL,et al.Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.J Control Release,2003;91(1-2):115
  • 5王向涛,李沙,张小滨,侯新朴.血栓靶向尿激酶脂质体的制备及其体内溶栓效果[J].药学学报,2003,38(3):231-235. 被引量：20
  • 6Gabizon A,Horowitz AT,Goren D,et al.Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes:in vitro studies.Bioconjug Chem,1999;10(2):289
  • 7陆伟跃,刘敏,潘俊,力弘,马俊.叶酸-脂质体制备及对HeLa细胞靶向作用[J].上海医科大学学报,2000,27(1):4-8. 被引量：23
  • 8Leamon CP,Cooper SR,Hardee GE.Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells:evaluation in vitro and in vivo.Bioconjug Chem,2003;14(4):738
  • 9Wang S,Lee RJ,Cauchon G,Gorenstein DG,et al.Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol.Proc Natl Acad Sci U S A,1995;92(8):3318
  • 10Aramaki Y,Lee I,Arima H,Sakamoto T,et al.Efficient gene transfer to hepatoblastoma cells through asialoglycoprotein receptor and expression under the control of the cyclin A promoter.Biol Pharm Bull,2003; 26(3):357

二级参考文献23

  • 1赵明,彭师奇,迪丽努尔,王银叶,周琴璐,赵文忠.含 RGD 四肽的合成与功能[J].药学学报,1997,32(4):271-277. 被引量：18
  • 2Naoto Oku, Yoshihiro Tokudome, Chieko Koike, et al.Liposomal Arg- Gly- Asp analogs effectively inhibit metastic B16 melanoma colonization in murine lungs[J].Life Sciences, 1996,58(24) : 2263.
  • 3Maria IC, Gyongyossy Issa, Werner Muller, et al .The covalent coupling of Arg - Gly - Asp - containing peptides to liposomes:purification and biochemical function of the lipopeptide [ J ]. Archives of Biochemistry and Biphysics, 1998,353(1): 101.
  • 4Ikuo Saiki,Junya Yoneda, Yu Igarashi, et al .Antimetastatic activity of polymeric RGDT peptides conjugated with poly(ethylene glycol) [J ] .Jpn J Cancer Res, 1993,84(3) : 558.
  • 5Peter C Brooks, Richard AF, Clark David A. Cheresh requirement of vescular integrin avβ3 for angiogenesis[ J ]. Science, 1994,264(22) : 569.
  • 6Hiromichi Kumagai, Mayumi Tajima, Yukio Ueno, et al.Effect of cyclic peptide on cell adhesion and tumor metastasis [ J ] . Biochem and Biophy Reseach Communications, 1991,177(1) : 74.
  • 7Straub JA,Atdyama A,Parmar P. In vitro plasma metabolism of RMP-7 [ J ]. Pharm Res, 1994,11 ( 1 ) : 1673.
  • 8Dagar S, Sekosan M, Lee KS, et al. VIP receptors as molecular targets of breast cancer: implicatios for targeted imaging and drug delivery [J ]. J Controlled Release ,2001,74( 1 ) : 129.
  • 9Graul A, Leeson P, Castaner J. RMP-7 Brandykinin B2 agonist,Blood brain barrier permeability enhancer [ J ]. Drugs Future,1998,23(1):32.
  • 10Grant R, Walker M, Hadley D, et al. Imaging response to chemotherapy with RMP-7 and carhoplatin in rnalignant glioma:size matters but speed does not [J]. J Neuroonco1,2002,57(3) :241.

共引文献59

同被引文献20

  • 1马超,匡安仁,唐恭顺,黄蕤.^(125)I-寡核苷酸-长循环脂质体的制备[J].四川大学学报（医学版）,2005,36(3):415-418. 被引量：4
  • 2Fenske DB, MacLachlan I, Cullis PR. Long-circulating vectors for the systemic delivery of genes. Curr Opin Mol Ther,2001 ,3 (2) : 153-158.
  • 3Song LY, Ahkong QF, Rong Q, etal. Characterization of the inhibitory effect of PEG-lipid conjugates on the intracellular delivery of plasmid and antisense DNA mediated by cationic lipid liposomes. Biochim Biophys Acta, 2002 , 1558(1) : 1-13.
  • 4Moreno A, Figueras A, Lloveras B,et al. Apoptosis in ductal carcinoma in situ of the breast. Breast J, 2001 ; 7 (4) : 245-248.
  • 5Chi KC, Wallis AE, Lee CH, et al. Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression. Breast Cancer Res Treat,2000,63(3):199-212.
  • 6Simoes-Wust AP, Olie RA, Gautschl O, et al. Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells. Int J Cancer, 2000 ; 87 (4):582-590.
  • 7Akhtar S, Hughes MD, Khan A, et al. The delivery of antisense therapeutics. Adv Drug Deliv Rev,2000344(1) :3-21.
  • 8Juliano R, Alam MR, Dixit V, et al. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res,2008,36(12):4158-4171.
  • 9Zelphati O, Szoka FC Jr. Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm Res,1996,13(90) :1367-1372.
  • 10Gautschi O, Tschopp S, Olie RA, et al. Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J Natl Cancer Inst, 2001 , 93 (6) : 463-471.

引证文献2

二级引证文献4

生物医学工程学杂志
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部