单组重复测量资料方差分析及趋势分析在中医辨证卒中单元研究中的应用

The Application of the ANOVA and Tendency Analysis of Within Subject Repeated Measures Data in the Traditional Chinese Medicine Stroke Unit

目的:运用单组重复测量资料方差分析,研究以中医辨证治疗为理论基础建立的卒中单元,治疗脑卒中病人神经功能缺损评分的时间变化特点。同时建立数学模型表达神经功能缺损程度随时间的数量变化趋势,找出疾病康复的变化规律,并对康复结果进行预测,为治疗提供参考信息。方法:首先应用重复测量资料的方差分析检验中医辨证治疗疗效在时间点上是否有差异,并用Bonferroni法做两两比较,找出具体有差异的时间点。最后用多项式函数配合方法建立回归方程,分析神经功能缺损评分随时间的变化趋势,做出预测。结果:入院第7天神经功能缺损评分比入院时降低,并且有统计学意义。入院14天评分比入院第7天及入院时均降低,且均具有统计学意义。神经功能缺损评分与时间呈线性趋势变化,在中医辨证卒中单元治疗下,神经功能缺损程度逐渐降低,疾病呈好转趋势。结论:单组重复测量资料的设计与分析揭示了中医辨证卒中单元病人神经功能缺损评分的时间变化特点及变化趋势,为卒中单元研究提供了新的设计与分析方法。

Objective： Apply the ANOVA of within subject repeated measures to research the changing feature of the patients NIHSS with time in traditional Chinese medicine stroke unit. At the same time construct mathematical model to respond the changing tendency of the NIHSS with time, so to find the rule of the rehabilitation and forecast the result, which can help to cure. Method： Firstly, apply ANOVA of the repeated measurement data to test whether there is difference in NIHSS with time. Secondly, by the method of Bonferroni to find between which time there is difference. Finally. construct regression equation by the method of polynomial function to analyses the tendency of the NIHSS, and to predict the NIHSS. Results. The NIHSSlowers in the time cured days than in the time of admission, and the loss has statistical significance. Likewise, the score cuts down in the time cured 14 days than in the time of admission and the time cured 7 days. Both the depression has statistical significance. The relationship between the NIHSS and the time shows linear tendency. Through the treatment, the NIHSS generally cuts down, and the disease shows better tendency. Conclusion： Within subject repeated measures provides new method of designation and analysis for the research of the stroke unit, which can reveal the changing feature and the tendency of patients＇ NIHSS in traditional Chinese medicine stroke unit.