多波长单因变量偏最小二回归校正法在他莫昔芬高效液相定量分析中的应用

Application of Partial Least Squares Regression Method to HPLC Data of Tomaxifen

使用偏最小二回归校正法处理他莫昔芬高效液相定量分析数据得到他莫昔芬的多波长标准方程,并将其与传统的单波长标准方程进行比较。结果显示多波长标准方程的平方相关系数大于单波长标准方程的平方相关系数,而多波长标准方程预测标准误小于单波长标准方程。

In this study, the HPLC multiwavelength data of tamoxifen was processed by using partial least squares regression method, and the calibration equation was aquired. Then it was comapared with the traditional single wavelength calibration equation, results showed that correlation coefficient of multiwavelength equation is more than single wavelength equation＇s, but the standard errors of prediction are less.