摘要
The novel carbazole derivative — 3-biacetyl-6-benzoyl-N-ethylcarbazole was synthesized through alkylation and Friedel-Crafts acylation from carbazole.The structure of the target compound was characterized by 1HNMR,13CNMR,UV,IR and elemental analysis.The optimal synthetical conditions for the monoacylation was achieved by carrying out orthogonal experiments:when the mole ratio of benzoyl chloride and N-ethyl-carbazole was1.2:1,while the mole ratio of catalyst and N-ethylcarbazole was 1.2:1 at 25℃for 3h.The yield was about 94.6%.
The novel carbazole derivative -3-biacetyl-6-benzoyl-N-ethylcarbazole was synthesized through alkylation and Friedel- Crafts acylation from carbazole. The structure of the target compound was characterized by IHNMR, 13CNMR, UV, IR and elemental analysis . The optimal synthetical conditions for the monoacylation was achieved by carrying out orthogonal experiments when the mole ratio of benzoyl chloride and N-ethyl-carbazole wasl. 2：1 ,while the mole ratio of catalyst and N-ethylcarbazole was 1.2：1 at 25℃ for 3h. The yield was about 94.6%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2007年第10期1162-1165,共4页
Chemical Research and Application
