期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

电压门控钠通道Na_V1.7与痛信号的产生 被引量：7

下载PDF
导出
摘要 电压门控钠通道NaV1.7选择性高表达在伤害感受性脊髓背根神经节的感觉神经元上,在疼痛电信号的产生、传导和调控中具有重要的生理功能。伤害性感受器上的NaV1.7亦在慢性神经痛和炎症痛的病理生理过程中发挥关键作用。近年来的研究发现,人类遗传性疼痛症(如红斑性肢痛病)与NaV1.7钠离子通道基因SCN9A的某些功能增强型突变相关。最近Cox等首次报道了SCN9A突变将导致人先天痛觉完全丧失,而无痛症患者机体其它功能正常,提示NaV1.7将可能成为有效治疗疼痛而无副作用的一个新靶标。
作者 杨晨颖 王克威
机构地区 北京大学神经生物学系/神经科学研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2007年第4期351-354,共4页 Progress in Physiological Sciences
基金 科技部863基金(2006AA02Z183) 理科基地创新人才培养基金资助课题
关键词 电压门控钠通道NaV1.7 SCN9A 慢性疼痛 红斑性肢痛症
分类号 R338 [医药卫生—人体生理学]
  • 相关文献

参考文献9

  • 1Cox JJ, Frank R, Emma Roberts,et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature, 2006, 444 : 894- 898.
  • 2韩济生.消除疼痛的最终理想还有多远——一种离子通道病显示出疼痛的根源[J].生理科学进展,2007,38(3):199-201. 被引量：2
  • 3Yu FH, Catterall WA. Overview of the voltage-gated sodium channel family. Genome Biol, 2003, 4 : 207 -213.
  • 4Waxman SG, Dib-Hajj S. Erythermalgia: molecular basis for an inherited pain syndrome. Trends Mol Med, 2005, 11:555-562.
  • 5Mohammed A, Caroline Stirling L, Greta F, et al. Nociceptor-specific gene deletion reveals a major role for Nav 1. 7 (PN1) in acute and inflammatory pain. PNAS, 2004, 101 : 12706- 12711.
  • 6Yang Y, Wang Y, Li S,et al. Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet, 2004, dl" 171 - 174.
  • 7Dib-Hajj SD, Rush AM, Waxman SG, et al. Gain-of-function mutation in Nav1. 7 in familial erythromelalgia induces bursting of sensory neurons. Brain, 2005, 128 : 1847 -1854.
  • 8Gardiner MR, Keith AP, Moffatt LS, et al. SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron, 2006, 52 : 767 -774.
  • 9George AL Jr. Inherited disorders of voltage-gated sodium channels. J Clin Invest, 2005, 115 : 1990 - 1999.

二级参考文献14

  • 1Michell SW.On a rare vaso-motor neurosis of the extremes,and on the maladies with which it may be confounded.Am J Med Sci,1878,76.
  • 2Drenth J,Finley WH,Breedveld GJ,et al.The primary erythermalgia susceptibility gene is located on chromosome 2q31-32.Am J Hum Genet,2001,68:1277～1282.
  • 3Yang Y,Wang Y,Li S,et al.Mutations in SCN9A,encoding a sodium channel alpha subunit,in patients with primary erythermalgia.J Med Genet,2004,41:171～174.
  • 4Han C,Rush AM,Dib-Hajj SD,et al.Sporadic onset of erythermalgia:a gain-of-function mutation in Nav1.7.Ann Neurol,2006,59:553～558.
  • 5Han C,Lampert A,Rush AM,et al.Temperature dependence of erythermalgia mutation L858F in sodium channel Nav1.7.BioMed Central,Molecular Pain,2007,3:3.
  • 6Zhang LL,Lin ZM,Ma ZH,et al.Mutation hotspots of SCN9A in primary erythermalgia.Bri J Dermat,2007,in press.
  • 7Waxman SG,Dib-Hajj SD.Erythermalgia:A hereditary pain syndrome enters the molecular era.Ann Neurology,2005,57:785～788.
  • 8Waxman SG.A channel sets the gain on pain.Nature,2006,444:831～832.
  • 9Nassar MA,Stirling LC,Mathews EA,et al.Nociceptor specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.PNAS USA,2004,101:12706～12711.
  • 10Cox JJ,Reimann F,Nicholas AK,et al.An SCN9A channelopathy causes congenital inability to experience pain.Nature,2006,444:894～898.

共引文献1

同被引文献58

  • 1张文,梁景平.牙齿感觉过敏症流体动力学说研究进展[J].牙体牙髓牙周病学杂志,2004,14(9):515-518. 被引量：16
  • 2陈彦平,郭丽娟,邢彦霞,何秀珍.口腔颌面部疼痛[J].疼痛,2004,12(3):101-106. 被引量：3
  • 3李其富,周东,羊洁,何俐.带状疱疹后神经痛循证医学防治实践[J].华西医学,2007,22(2):228-230. 被引量：7
  • 4宋文阁,傅志俭,主译.临床疼痛学[M].3版.山东:山东科学技术出版社,2004,180.
  • 5徐世正,主译.安德鲁斯临床皮肤病学[M].2版.北京:科学出版社,2008:398-399.
  • 6Hargreaves KM. Orofacail pain[ J] . J Pain,2011,152(3) :25-32.
  • 7Beneng K,Renton T,Yilmaz Z,et al. Sodium channel Navi. 7 im~munoreactivity in painful human dental pulp and burning mouthsyndrome[ J]. J BMC Neurosci,2010,11 (71 ) :1-7.
  • 8Luo S, Perry GM, Levinson SR, et al. Navi. 7 expression is in-creased in painiul human dental pulp [ J ]. J Mol Pain, 2008,4(16):1-13.
  • 9Magloire H,Maurin JC,Couble ML,et al. Dental pain and odonto-blasts :facts and hypotheses [ J ]. J Orofac Pain,2010, 24 ( 4 ):335-349.
  • 10Allard B,Magloire H,Couble ML,扣 al. Voltage-gated sodium chan-nels confer excitability to human odontoblasts possible role in toothtransmission[ J]. J Bio] Chem,2006,281 (39) ;29002-29010.

引证文献7

二级引证文献5

生理科学进展
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部