白细胞介素-10在系统性红斑狼疮中的表达及意义

Serum Level of Interleukin-10 in Patients with Systemic Lupus Erythematosus and its Clinical Significance

目的探讨白细胞介素-10(inter leukin-10,IL-10)在系统性红斑狼疮(systemic lupus trythematosus,SLE)中的表达及其临床意义。方法54例SLE患者按SLE活动性指数(systemic lupus erythematosus disease activity index SLEDAI)积分分为活动组(27例)和稳定组(27例);对照组为30例健康人。采用双抗体夹心酶联免疫吸附试验(ELISA)检测血清IL-10水平,并分析其与SLEDAI积分之间的关系。结果活动组SLEIL-10水平([52.13±10.24)pg/ml]显著高于稳定组SLE([19.55±8.76)pg/ml]和正常对照组[(13.25±3.12)pg/ml](<0.01);并且IL-10表达量与SLE活动组SLEDAI积分呈高度正相关(=0.7946,<0.01),与SLE稳定组SLEDAZ积分呈低度正相关(=0.3872,<0.05)。结论IL-10的表达水平和SLE的病情呈正相关;检测IL-10对SLE病情的判断及指导治疗有一定的价值。

Objective To investigate the serum level ofinterleukin-10 （IL-10） and its clinical significance in patients with systemic lupus erythematosus （SLE）. Methods The serum level of IL- 10 of 54 SLE patients（the active and stable group, each 27 patients） and 30 normal controls were measured by the way of ELISA,then the serum level oflL-10 and systemic lupus erythematosus disease activity index （SLEDAI） was analyzed accordingly by correlation analysis. Results The serum IL-10 level of the active SLE patients （52.13±10.24 ）pg/ml were significantly higher than that of the stable SLE patients（ 19.55±8.76） pg/ml and controls（13.25±3.12） pg/ml, （P 〈 0.01 ）.The serum IL-10 level positive correlated with SLEDAI in patients with active SLE（r=0.7946,P 〈 0.01）. Conclusion IL-10 may play an important role in the pathogenesis of SLE. The serum IL-10 level positive correlated with the state of patients with SLE and may be of useful clinical value in judging SLE disease activity and its treatment.