脆性组氨酸三联体与细胞信号转导研究进展

Progress on fragile histidine triad and cell signal transduction

脆性组氨酸三联体（FHIT）基因是一种抑癌基因，其与许多肿瘤的发生有密切的关系。近几年有关FHIT基因的研究，侧重于辐射后FHIT及其上下游调控基因之间的关系和作用方式，包括ATRJCHK1、bcl-2基因、caspase家族、环孢霉素A和核因子-κB之间的作用。

Fragile histidine triad （FHIT） gene is a new tumour surpress gene. During the past decade ,evidence has accumulated in surport that plays a roll in many tumors. In this review, describe the recent finding between FHIT and upstream or downsream gene in post-radiation, including ATR/CHK1 gene, bcl-2 geme, caspase family, cyclophilin A gene and nuclear factor-κB.