期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白细胞介素24的研究进展

Progress of interleukin-24 study
原文传递
导出
摘要 白细胞介素24是白细胞介素10家族的成员，其除细胞因子本质外，还能够诱导不同的肿瘤细胞凋亡，而对正常细胞没有影响。它能促进旁观者抗肿瘤效应，在动物模型中能抑制肿瘤生长和血管形成，具有辐射增敏作用和调节免疫反应作用。 Interl eukin-24 （I1-24） is a member of interleukin- 10 family. Besides its character as a cytokine, IL-24 could induce apoptosis of different kinds of tumor cells without any harmful effects to normal cells. IL-24 could both promote bystander anti-tumor effect, inhibit tumor growth and angiogenesis in animal models. It also has effects of radiosensitization and immunoregulation.
作者 刘永哲 金顺子
机构地区 吉林大学公共卫生学院卫生部放射生物学重点实验室
出处 《国际放射医学核医学杂志》 2007年第3期179-182,共4页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 白细胞介素类 细胞凋亡 辐射耐受性 Interleukins Apoptosis Radiation tolerance
分类号 R [医药卫生]
  • 相关文献

参考文献20

  • 1Jiang H, Lin J J, Su ZZ, et al. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene, 1995, 11(12): 2477-2486.
  • 2Caudell EG, Mumm JB, Poindexter N, et al. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. J Immunol, 2002, 168(12): 6041-6046.
  • 3Huang EY, Madireddi MT, Gopalkrishnan RV, et al. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Oncogene, 2001, 20 (48): 7051-7063.
  • 4Fisher PB, Gopalkrishnan RV, Chada S, et al. Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biol Ther, 2003, 2(4): 23-37.
  • 5Lebedeva IV, Su ZZ, Sarkar D, et al. Melanoma differentiation associated gene-7, mda-7/Interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. Cancer Res, 2003, 63 (23): 8138 - 8144.
  • 6Pataer A, Vorburger SA, Barber GN, et al. Adenoviral transfer of the melanoma differentiation-associated gene-7 induces apoptasis of lung cancer cells via up-regulation the double-stranded RNA- dependent protein kinase (PKR). Cancer Res, 2002, 62(8): 2239- 2243.
  • 7Sarkar D, Su ZZ, Lebedeva IV, et al. Mda-7/IL-24 mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38MAPK. Proc Natl Acad Sci USA, 2002, 99 (15): 10054-10059.
  • 8Sauane M, Lebedeva IV, Su ZZ, et al. Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Res, 2004, 64(9): 2988-2993.
  • 9Su Z, Lebedeva IV, Gopalkrishnan RV, et al. A eombinatorialapp roach for selectively inducing programmed cell death in human pancreatic cancer cells. Proc Natl Acad Sci USA, 2001, 98 (18): 10332-10337.
  • 10Ramesh R, Mhashilkar AM, Tanaka F, et al. Melanoma differentiation-associated gene 7/Interleukin (IL) -24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. Cancer Res, 2003, 63 (16): 5105-5113.
国际放射医学核医学杂志
2007年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部