乙二醇葡糖苷的分离纯化

The Separation and Purification of the Glycol Glucosides

以葡萄糖和乙二醇为原料,以磷酸为催化剂,制备了乙二醇葡糖苷。采用萃取的方法对乙二醇葡糖苷进行初步分离,再用G15交联葡聚糖凝胶进行层析柱分离,以质量分数0.2‰的迭氮化钠溶液做流动相,体积流量为0.9 mL/min,可使乙二醇与乙二醇葡糖苷完全分离,实现除去乙二醇的目的。

Glycol glucosides were synthesized from glucose and glycol catalyzed by phosphorous acid. The primary separation to eliminate the glycol from glycol glucosides was carried out by extraction method with butyl alcohol. The purification eliminated glycol by gel filtration chromatography with G15 sephadex column. The mobile phase was 0. 002% NaNa3 water solution. The velocity of flow is 0. 9 mL/min. The methods could completely eliminate the glycol from glycol glucosides products.