一种识别蛋白质的保守氨基酸残基的新方法

A New Method of Identifying Protein Conserved Amino Residues

保守氨基酸残基在生物进化过程中具有较强的稳定性,一般不会发生太大的变化;生物信息学认为:氨基酸序列决定蛋白质结构,蛋白质结构决定蛋白质功能。因此,作者基于氨基酸的生化特性、几何特性和动态特性描述了一个新颖的算法去发现蛋白酶家族中的保守氨基酸残基,而保守氨基酸残基将对蛋白质的结构和功能的研究具有重要的意义。

Conserved amino residues have good stability and do not change during the process of the biology evolution, it is accepted that. amino sequence decides protein structure and protein structure decides protein functions in bioinformatics. Based on these facts, a novel algorithm is designed to identify each protein conserved amino residues of the protease families. The proposal algorithm is based on the dynamic, biochemical and geometric features of amino acid. By the way, the conserved amino residues play key role on the protein structural and functional.