P53在膀胱移行细胞癌的表达及临床意义

P53 Gene Product Expressions and Their Clinical Significance in Transitional Cell Carcinoma of the Bladder

目的探讨P53在膀胱移行细胞癌的表达与膀胱移行细胞癌生物学行为的关系及临床意义。方法采用免疫组化(SABC)检测62例膀胱移行细胞癌中P53的表达情况。结果P53表达阳性率均随着膀胱癌的病理分级、临床分期上升而升高,且有统计学意义(P<0.05),P53阳性者的复发率明显高于阴性表达者,且有统计学意义(P<0.05)。结果本研究显示,P53表达水平与膀胱移行细胞癌组织学分级、临床分期及复发密切相关,随着膀胱移行细胞癌分级的增高而显著增高,浸润性膀胱移行细胞癌(T2-T4期)表达水平高于表浅性膀胱移行细胞癌(Tis-T1期);复发性膀胱移行细胞癌的表达水平明显高于初发性膀胱移行细胞癌。结论P53检测能为判断膀胱移行细胞癌的恶性程度和复发提供依据。

Objective To investigate the expressions of P53 gene products and their relationship with neoplastic biological behavior in transitional cell carcinoma of the bladder and their clinical significance as well. Methods The expressions of P53 gene products of 62 patients with transitional cell carcinoma of the bladder were evaluated using immunohistological method（SABC）. Results The rate of positive expression of P53 gene product increased with the increase of histological grade and clinical stage and there was statistical significance（P〈0.05）.The rate of recurrence of patients P53 positively expressed was significantly higher than that of patients P53 negatively expressed and statistical significance was found as well（P〈0.05）. Conclusion The essay demonstrated that P53 gene product expressions was associated with histological grade,clinical stage and recurrence of transitional cell carcinoma of the bladder. Their expressions increased significantly with the increase of histological grade. Their expressions in invasive transitional cell carcinoma of the bladder（T2-T4）were much higher than in superficial phenotype（Tis-T1）.Their expressions in recurrent cases were higher than in the other cases. The essay suggested that P53 might be used as objective indicators of malignance and recurrence of transitional cell carcinoma of the bladder.