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载脂蛋白A5基因-1131T>C多态性与回、汉族血脂相关性的研究 被引量：2

The relationship between the polymorphism of apolipoprotein A5 gene-1131T>C and the level of serum triglyceride in Hui and Han nationality
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摘要 目的研究载脂蛋白A5基因-1131T>C多态性位点与血甘油三酯的关系。方法对226例回、汉族健康人应用聚合酶链反应-限制片多态性方法进行基因分型。结果-1131T>C的3种基因型在回、汉族人群中的分布有差异性,但稀有等位基因C的分布频率无差异性;回、汉两民族携带C等位基因的个体(TC和CC型)的TC、TG、LDL-C、APOA、ApoB水平均比非携带C等位基因(TT型)个体略高,但无显著性差异(P>0.05)。结论-1131T>C对回、汉族血脂水平影响无显著性差异,与回、汉族血脂水平无相关性。 Objective To explore the relationship between the polymorphism of apolipoprotein A5 gene - 1131T 〉 C and the level of serum lipids and lipoproteins. Methods 226 subjects were collected to determine the genotype by using polymerase reaction restriction fragments length polymorphism （ PCR - RFLP）. Results The frequencies of three genotypes of - 1131T 〉 C were significantly different in Hui and Han nationality. The frequencies of minor allele for - 1131T 〉 C was not different between Hui and Han nationality. It was found that people carried minor allele with higher lipids level than people carried major allele in either group, but there was no sig- nificant difference （ P 〉 0.05 ）. Conclusion Variation in APOA5 gene has no influence on lipids in Hui, Han nationality.
作者 姚成立 李溪 宋梅 马俊花 宁海峰 胡斌
机构地区 宁夏医学院第二附属医院 广州市中山大学医学院
出处 《宁夏医学杂志》 CAS 2007年第10期881-882,共2页 Ningxia Medical Journal
基金 2005年宁夏自然科学基金项目(项目号:NZ0562)
关键词 载脂蛋白A5 基因多态性 基因分型 血脂 Apolipoprotein A5 Gene Polymorphism Genotype Lipids
分类号 R394.4 [医药卫生—医学遗传学]
  • 相关文献

参考文献7

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  • 2Van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein AV:a novel apolipoprotein associated with an early phase of liver regeneration[J]. J Biol Chem,2001,276(48) :512 -520.
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二级参考文献12

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共引文献7

同被引文献25

  • 1李向平,赵水平,聂赛,彭道泉.载脂蛋白A5-1131T>C基因多态性对血脂的影响[J].医学临床研究,2004,21(11):1245-1249. 被引量：8
  • 2Pennacchio LA, Olivier M, Hubacek JA, et al. An appolipoprotein influencing triglyeeride in humans and mice revealed by comparative sequencing[ J]. Science,2001,294(5540) : 169-173.
  • 3van der Vliet HN, Sammels MG, Leegwater AC, et 81. Apolipoprotein AV: a novel Apolipoprotein associated with an early phase of liver regeneration[J]. J Biol Chem,2001,276(48) :512-520.
  • 4Albom WE, Johnson MG, Prince MJ, et al. DeflnifiveN terminal- pr0teinsequence and further characterization of the novelApolipoprotein ASinhuman semm[J]. Clin Chem, 2006,52(3) :514-517.
  • 5Florvall G, Basu S, l_arsson A. Apolipoprotein A1 is a stronger prognostic marker than are HDL and LDL eho-lesterol for cardiovascular disease and mortality in elderly men[J]. J Gerontol A Biol Sci Med Sci, 2006,61 (12) : 1262.
  • 6Comamschl M, Putt WE, Pozzl S, et al. Stracture and function of the ApoA-IV T347S and Q360H common variants [ J]. Bioehem Biophys Res Commun, 2010,393 ( 1 ) : 126-130.
  • 7Culnan DM, Cooney RN, Stanley B, et al. Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass [ J ]. Obesity ( Silver Spring), 2009,17 ( 1 ) :46-52.
  • 8Endo K, Yanagi H, Araki J, et al. Association found between the promoter region polymorphism in the ApolipoproteinAV gene and the serum trigiyc-eride level in Japanese schoolchildren[ J]. Hum Genet, 2002,111 (6) :570-572.
  • 9van der Vliet HN, Schaap FG, Levels JH, et al. Adenoviral overexpression of Apolipoproteion A-V reduces serum levels of triglycer- ides and cholesterol in mice [ J]. Biochem Biophys Res Commun, 2002,295(5) :1156-1159.
  • 10PENNACCHIO L A, OLIVIER M, HUBACEK J A, et al. An appoli- poprotein influencing triglyceride in humans and mice revealed by comparative sequencing[J]. Science, 2001, 294 (5540): 169-173.

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二级引证文献5

宁夏医学杂志
2007年 第10期

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