祛异康对子宫内膜异位症大鼠腹腔液IL-2、IL-6的影响

Effect of Qu Yi Kang on the Celiac Liquid IL-2 and IL-6 of Endometriosis Rats

目的:观察中药祛异康对子宫内膜异位症大鼠腹腔液IL-2、IL-6的影响,探讨其治疗子宫内膜异位症的机理。方法:将40只健康雌性SD大鼠随机分为4组:A组只行开关腹,B、C、D组均行内膜移植,造模完成后,A、B组以生理盐水灌胃,C、D组分别给予中药祛异康、西药丹那唑灌胃,4周后开腹收集腹腔液测定IL-2I、L-6表达水平。结果:祛异康可以降低异位症大鼠腹腔液中IL-2及IL-6浓度(P<0.05;P<0.01)。结论:祛异康能明显改善腹腔微环境,其治疗子宫内膜异位症的作用机理可能是通过改变腹腔液微环境,降低细胞因子IL-2、IL-6的水平,从而抑制异位内膜生长来实现的。

Objective: To observe the effect of Qu Yi Kang on the celiac liquid IL-2 and IL-6 of endometriosis rats and explore its treatment mechanism.Methods: 40 healthy female rats were divided into 4 groups.Group A was given an open-and-close abdominal operation.Group B,C and D were equally given intimal transplants.After the models were made,group A and B were infused with normal salt solution while group C and D were infused with Qu Yi Kang(traditional Chinese medicine) and Dan Na Chuo(western medicine).After 4 weeks,the collection of celiac liquid by the open-and-close abdominal operation was determined to the level of IL-2 and IL-6.Results: Qu Yi Kang could decease the density of IL-2 and IL-6 of the endometriosis rats(P<0.05;P>0.01).Conclusion: Qu Yi Kang can obviously improve the abdominal microcirculation and its treatment mechanism may probably operate by decreasing the level of IL-2 and IL-6 cell agent to inhibit the production of the endometriosis.