西咪替丁、更昔洛韦及利巴韦林治疗小儿水痘的疗效比较

The effect of cimetidine,gancidovir and ribavirin on pediatric varicella

目的:比较西咪替丁、更昔洛韦及利巴韦林治疗小儿水痘的疗效及安全性。方法:90例水痘患儿随机分为三组,利巴韦林组30例用利巴韦林注射液10mg/(kg·d);更昔洛韦组30例用更昔洛韦注射液5 mg/(kg·d);西咪替丁组30例用西咪替丁注射液15 mg/(kg·d),三组均1次/d静脉滴注,疗程5d,其他治疗相同。结果:西咪替丁组总有效率86.67%,更昔洛韦组总有效率93.33%,利巴韦林组总有效率63.33%;西咪替丁组和更昔洛韦组症状、体征好转时间比较差异无统计学意义(P>0.05),与利巴韦林组比较差异有统计学意义(P<0.05或P<0.01)。结论:西咪替丁和更昔洛韦治疗小儿水痘疗效显著,短期使用安全性好。

Objective： To investigate the effect and safety of cimetidine, ganciclovir and ribavirin in the treatment of pediatric varicella. Methods： 90 patients with pediatric varicella were randomly divided into three groups. Cimetidine group were given cimetidine in dosage of 15 mg/（kg.d） ; ganciclovir group were presented ganciclovir 5 mg/（kg.d） and ribavirin group were given ribavirin 10 mg/（ kg. d）. Three groups were all treated one time per day for five days. Results： Cimetidine group had an efficiency of 86.67 %, ganciclovir group an efficiency of 93.33 % and ribavirin group an efficiency of 63.33 %. The clinic symptoms and signs in cimetidine group and ganciclovir group got better more quickly than those in fibavirin group （P 〈 0.05 ＆ P 〈 0.01 ）, but there was no difference between the former two groups （P 〉 0.05）. Conclusions： Cimetidine and ganciclovir were of obvious effect and safety in the treatment of pediatric varicella.