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促性腺激素释放激素激动剂降调节中发生妊娠的原因及处理 被引量：7

The causes and managemnt of pregnancy achieved in GnRH agonist downregulation
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摘要 Spontaneous pregnancy may be achieved in GnRH-a down-regulation.The main causes are that GnRH-a is given inadvertently during early pregnancy and the flare-up effect of GnRH-a administration induces ovulation.There has been concern regarding the luteolytic effect of the agonist and teratogenicity.Most investigators think that these pregnancies produce normal offspring and needn’t be terminated.When a pregnancy is confirmed,luteal support should be continued untill the 12th gestational week. Spontaneous pregnancy may be achieved in GnRH-a down-regulation. The main causes are that GnRH-a is given inadvertently during early pregnancy and the flare-up effect of GnRH-a administration induces ovulation. There has been concern regarding the luteolytic effect of the agonist and teratogenicity. Most investigators think that these pregnancies produce normal offspring and needn＇t be terminated. When a pregnancy is confirmed, luteal support should be continued untill the 12th gestational week.
作者 李尚为 傅锦媚
机构地区 四川大学华西第二医院生殖医学中心
出处 《生殖医学杂志》 CAS 2007年第5期321-322,共2页 Journal of Reproductive Medicine
关键词 促性腺激素释放激素激动剂 降调节 妊娠 黄体溶解 致畸性 GnRH agonist Down-regulation Pregnancy Luteolysis Teratogenicity
分类号 R711.6 [医药卫生—妇产科学]
  • 相关文献

参考文献3

  • 1周灿权,钟依平,庄广伦,梁晓燕,李洁,方丛.使用促性腺激素释放激素激动剂中发现妊娠26例分析[J].中国实用妇科与产科杂志,2003,19(6):353-355. 被引量：8
  • 2Platteau P,Gabbe M,Famelos M,et al.Should we still advise infertile couples to use (barrier) contraception before IVF down-regulation?[J].Fertil Steril,2000,74(4):655-659.
  • 3Cahill DJ.Risks of GnRH agonist administration in early pregnancy[A].In:Marco F,Carlo F (eds).Ovulation induction update 1998[M].New York:The Parthenon Publishing Group,1998.97-105.

二级参考文献9

  • 1庄广伦,顾正田.Buserelin在体外受精超排卵中的作用及其对排卵前卵泡液的影响[J].中华妇产科杂志,1993,28(1):10-13. 被引量：21
  • 2Akagbosu FT. The use of GnRH agonists and antagonists in infertility. In:Peter R,Brinsden,eds. A textbook of in vitro fertilization and assisted reproduction. 2nd eding Group, 1999.83.
  • 3Porter RN, Smith W, Craft IL, et al. Induction of ovulation for in vitro fertilization using buserelin and gonadotropins. Lancet, 1984,2(8414) : 1284.
  • 4Cahill DJ. Risks of GnRH agonist administration in early pregnancy. In: Marco F, Carlo F, eds. Ovulation Induction Update' 98. London:The Parthenon Publishing Group, 1998.97.
  • 5Wilshire GB, Emmi AM,Gagliardi CC,et al. Gonadotropin- releasing hormone agonist administration in early human pregnancy is associated with normal outcomes. Fertil Steril, 1993,60( 6 ) :980.
  • 6Haelow CR,CahiU DJ,Maile LA, et al. Reduced preovulatory granulosa cell steroidogenesis. In: Women with endometriosis. J Clin Endocrin Metab, 1996,81(1 ) :426.
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  • 8Forman R,Robinson J,Egan D,et al. Ectopic pregnancy after luteal phase initiation of gonadotropin- releasing hormone analogue before in vitro fertilization. Fertil Steril, 1990,54(1 ):169.
  • 9周灿权,钟依平.促性腺激素释放激素激动剂的临床应用[J].中国实用妇科与产科杂志,1999,15(12):754-756. 被引量：10

共引文献7

同被引文献22

  • 1赵军招,叶碧绿,林金菊,林文琴,黄学锋.经阴道小卵泡穿刺术治疗耐克罗米芬多囊卵巢综合征的临床研究[J].生殖医学杂志,2006,15(2):81-83. 被引量：14
  • 2Cahill D J, Risk of GnRH agonist administration in early pregnancy. In:Marco F,Carlo F,eds.Ovulation Induction Update'98. London: The Prathenon Publishing Group. 1998.97.
  • 3Wilshire GB, Emmi AM, Gagliardi CC, et al. Gonadotropin-releasing hormone agonist administration in early human pregnancy is associated with normal outcomes. Fertil Steril, 1993, 60(6):980.
  • 4Forman R,Robinson J ,Egan D ,et al . Ectopic pregnancy after luteal phase initiation of gonadotropin - releasing hormone analogue before in vitro fertilization. Fertil Steril , 1990,54 (1) :169.
  • 5Porter RN, Smith W, Craft IL, et al. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins[J]. Lancet, 1984, 2(8414) :1284-1285.
  • 6Cahill DJ. Risks of GnRH agonist administration in early pregnancy[A]. In: Marco F, Carlo F, (eds). Ovulation induction update 1998 [ M ]. London: The Parthenon Publishing Group, 1998z 97-105.
  • 7Forman R, Robinson J, Egan D, et al. Ectopic pregnancy after luteal phase initiation of gonadotropin-releasing hormone analog before in vitro fertilization[J]. Fertil Steril, 1990,54 (1) : 169-170.
  • 8Platteau P, Gabbe M, Famelos M, et al. Should we still advise infertile couples to use (barrier) contraception before IVF down-regulation? [J]. Fertil Steril, 2000, 74 (4):655-659.
  • 9Facchinetti F, Tarabusi M, Volpe A. Cognitive-behavioral treatment decrease cardiovascular and neuroen - docrine reaction to stress in women waiting for assisted reproduction [ J]. Psychoneuroendocrinology, 2004,29(2) : 162-173
  • 10LAHAT E,RAZIEL A,FRIEDLER S, et al. Long - term follow -up of children bom after inadvertent administration of a gonadotro-pin 一 releasing hormone agonist in early pregnancy [ J ].Hum Re-prod, 1999,14(10) : 2656-2660.

引证文献7

二级引证文献17

生殖医学杂志
2007年 第5期

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